The ototoxicity of antibiotics given either systemically or topically has been recently recognized. However, the ototoxicity of topically applled alcohols and other solvents used as vehicles for drugs has not been well recognized. One of the most common solvents, propylene glycol, was chosen for ...
Stable aqueous propylene glycol solutions of aluminum gluconate complexes of certain tetracycline antibioticsREMMERS EDWARD GRANTSIEGER GEORGE MADISONBARRINGER WILLIAM CHARLES
doi:US3166474 AMadison, Sieger GeorgeCharles, Barringer WilliamGrant, Remmers EdwardUSUS3166474 1961年5月26日 1965年1月19日 American Cyanamid Co Stable aqueous propylene glycol solutions of aluminum gluconate complexes of certain tetracycline antibiotics...
PURPOSE: Provided is a novel method for manufacturing intermediate of cefatrizine propylene glycol, which is useful as antibiotics, from 7-aminocephalosporanic acid, in high yield and purity. CONSTITUTION: The intermediate of cefatrizine propylene is 7-amino-3-(5-(1,2,3-triazol)thiomethyl)-...
A substantially non-aqueous medicant vehicle containing from 15 to 45 parts saturated fatty alcohol having from 16 to 24 carbons, from 45 to 85 parts glycol solvent, from 0 to 15 parts plasticizer, from 0 to 15 parts coupling agent, 0 to 20 parts penetrant, and if desired, other ...
propylene glycol, (c) from 10 to 25 weight per cent of a compatible co-solvent, the total concentration of (b) and (c) being less than 80 weight per cent, (d) from 0 to 15 weight per cent of compatible plasticizer, the combined concentration of (c) and (d) being greater than 20...
We then developed an ex vivo degradation assay and correlated the mechanical properties of degrading cement with the temporal changes in chemical properties of both the cement and the bathing medium. The optimal cement formulation was composed of one-third poly(propylene glycolfumarate)-(methyl...
propylene glycol, (c) from 10 to 25 weight per cent of a compatible co-solvent, the total concentration of (b) and (c) being less than 80 weight per cent, (d) from 0 to 15 weight per cent of compatible plasticizer, the combined concentration of (c) and (d) being greater than 20...
propylene glycol, (c) from 10 to 25 weight per cent of a compatible co-solvent, the total concentration of (b) and (c) being less than 80 weight per cent, (d) from 0 to 15 weight per cent of compatible plasticizer, the combined concentration of (c) and (d) being greater than 20...
propylene glycol, (c) from 10 to 25 weight per cent of a compatible co-solvent, the total concentration of (b) and (c) being less than 80 weight per cent, (d) from 0 to 15 weight per cent of compatible plasticizer, the combined concentration of (c) and (d) being greater than 20...