Sign up with one click: Facebook Twitter Google Share on Facebook proprotein [pro-pro´tēn] a protein precursor that is cleaved to form an active protein, e.g., proinsulin, the precursor of insulin. Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh ...
proprotein convertase subtilisin kexin type 9squalene synthaseAlmost two decades after their identification, the components of the mitotic checkpoint are finally ... M Mapelli,A Musacchio - 《Current Opinion in Structural Biology》 被引量: 144发表: 2007年 PACE4 expression in mouse basal keratinocytes...
The purpose of this study was to determine the effect of proprotein convertase subtilisin/kexin type 9 (PCSK9) deficiency on development of DVT in mice. Pcsk9 deficient (pcsk9/) and wild-type (WT) littermates underwent partial inferior vena cava (IVC) ligation to induce venous thrombosis. ...
Proprotein convertase, subtilisin/kexin type 9 (PCSK9), a key regulator of plasma LDL-cholesterol (LDL-c) and cardiovascular risk, is produced in liver and... JD Browning,JD Horton - 《Journal of Lipid Research》 被引量: 169发表: 2010年 Fasting reduces plasma proprotein convertase, subtilisin...
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has evolved as a pivotal enzyme in lipid metabolism and a revolutionary therapeutic target for hypercholesterolemia and its related cardiovascular diseases (CVD). This comprehensive review delineates the intricate roles and wide-ranging implications of...
Prodomain of the proprotein convertase subtilisin/kexin Furin (ppFurin) protects from tumor progression and metastasis. Carcinogenesis. 2014;35:528–36. Article CAS PubMed Google Scholar He Z, Khatib A-M, Creemers JWM. Loss of proprotein convertase furin in mammary gland impairs proIGF1R and ...
'LDL-C' = LDL-C plus Lp(a)-C: implications of achieved ultra-low LDL-C levels in the proprotein convertase subtilisin/kexin type 9 era of potent LDL-C lowe... `LDL-C' = LDL-C + Lp(a)-C: implications of achieved ultra-low LDL-C levels in the proprotein convertase subtilisin/...
Intestinal epithelial cells (IECs) in dysbiosed gut synthesize reduced levels of proprotein convertase subtilisin/kexin type 9 (PCSK9), the key regulator of LDL-C clearance. The expression of PCSK9 in IECs depends on the host metabolic status and dietary habits. Decreased production of PCSK9 ...
Genetic analysis has identified PCSK9 (proprotein convertase subtilisin/kexin type 9) as a crucial gene in the regulation of LDL-cholesterol via control of LDL receptor degradation. Although biochemical characteristics and clinical implications of PCSK9 have been extensively investigated, epigenetic ...
1. Introduction Elevated circulating low-density lipoprotein-cholesterol (LDL-C) is a risk factor for cardiovascular disease [1]. Clearance of plasma LDL-C is primarily mediated by hepatic LDL receptors (LDLR) [2]. This clearance is opposed by proprotein convertase subtilisin/kexin type 9 (PCSK...