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3.1. Accumulation of toxic poly(GA) aggregates detrimentally impairs ubiquitin-dependent catabolism in neurons We employed a AAV9-poly(GA)175-EGFP (henceforth poly(GA)) previously generated and characterized by our group (Catanese et al., 2021) to investigate how cytotoxic protein aggregates affec...
Hence, an optimized mucoadhesion is required for a film to be effectively used as a drug delivery system [21]. There are four possible general interactions between mucoadhesive polymers and glycoproteins: (1) Covalent attachment; (2) electrostatic interaction, which requires matching of charge ...