AIM To study the influence of inducers BNFand PB on the stereoselective metabolism ofpropranolol in rat hepatic microsomes.METHODS Phase Ⅰ metabolism of propranololwas studied by using the microsomes induced byBNF and PB and the non-induced microsome asthe control.The enzymatic kinetic parameters of...
AIM To study the influence of inducers BNF and PB on the stereoselective metablism of propranolol in rat hepatic microsomes. METHODS Phase I metabolism of propranolol Was studied by using the microsomes induced by BNF and PB and the non-induced microsome as The control. The enzymatic kinet...
Compared with the control, microsome induced by BNF enhanced enzyme activity to propranolol R (+)enantiomer, and microsome induced by PB showed less enzyme activity to propranolol S (-)-enan tiomer which remains the same stereoselectivities as that of the control.CONCLUSION: Enzyme activity ...