and growth in living organisms. Mitosis is important because it ensures that all new cells that are generated in a given organism will have the same number of chromosomes and genetic information. In order to accomplish this goal,mitosis occurs in four discrete, consistently consecutive phases: 1)...
The segregation of the germ cell from the somatic lineage occurs very early during development in both invertebrates and vertebrates. Once the primordial germ cells (PGC) get committed to the germ cell lineage and enter meiosis, they progress to prophase I, where the first meiotic cycle is then...
ProphaseI is the defining stage of meiosis in that it is unique from mitotic prophase and in that it encompasses many of the I unique features of meiosis, including formation of thesynaptonemal complex(SC), pairing of homologous (maternal and paternal) chromosomes, and formation of chiasmata be...
Entry into meiosis can be defined both through a drastic change in gene expression and through initiation of the nuclear events of the MPI. MPI is relatively long and is typically divided into four successive stages: leptotene, zygotene, pachytene and diplotene, which are preceded by the prele...
An additional step called crossing over occurs during prophase I of meiosis. This leads to additional genetic variation in gametes.What is Prophase? Mitosis and meiosis sound alike and also have similar phases. However, the purpose and outcome of these two processes is very different. Prophase is...
In meiosis I, a coordinated chain of events in the extended prophase I results in pairing, synapsis of homologous chromosomes and recombination of non-sister chromatids in each bivalent. Chromosome number is cut in half in anaphase I owing to the separation of homologous chromosomes18. During ...
Meiosis usually has two cycles of segregation of chromosomes and thus twice undergoes prophase, leading to prophase I and prophase II. In all meiosis, Prophase I is the most complex stage because homologous chromosomes have to pair and exchange genetic information. The mitotic prophase is very simi...
To understand how the LINC complex is connected to telomeres in meiosis, we employed yeast two-hybrid (Y2H) interaction analysis to systematically examine the potential interactions between SUN1 with telomeric shelterin proteins and meiotic factors that have been reported to play important roles at tel...
138673, Republic of Singapore; 3Department of Biochemistry, National University of Singapore (NUS), Singapore 117597, Republic of Singapore A unique feature of female germ cell development in mammals is their remarkably long arrest at the prophase of meiosis I, which lasts up to 50 years in ...
In mammalian cells, part of the CDC2 protein is associated with centrosomes and with the mitotic apparatus during mitosis 4, 5, 6, 7. In fission yeast, CDC2 co-localizes with its regulatory subunit, cyclin B, to the spindle pole bodies 8, 9. During meiosis re-initiation of starfish ...