In 1935, Pincus and Enzmann were the first to show that the removal of prophase I arrested rabbit oocytes from their follicular environment resulted in the spontaneous resumption of meiosis (Pincus and Enzmann, 1935). This finding supported a model where the surrounding somatic cells regulated maint...
1.The first stage of mitosis, during which the chromosomes condense and become visible, the nuclear membrane breaks down, and the spindle apparatus forms at opposite poles of the cell. 2.The first stage of meiosis, constituted by a series of events that include the thickening and coiling of ...
the meiotic programme diverges from the mitotic programme, and multiple meiosis-specific features are coordinately implemented to prepare for the later orderly halving of the genome1. Thus, the
1). Sign in to download full-size image Fig. 1. Stages of oogenesis and folliculogenesis in the mouse. Primordial germ cells (PGCs) divide mitotically giving rise to oogonia that populate the genital ridge. Around embryonic day 12.5–13.5, oocytes enter prophase I of meiosis, that includes ...
meiosis has indicated that loss of CDKA;1 resulted in complete sterility62,63. The TE5A mutants were infertile due to meiotic arrest at prophase I. One gene (Fna032795) encoding cyclin-dependent kinase C;1 (CDKC;1) and another gene encoding Cdk-activating kinase assembly factor (MAT1) (...
V. Ford-Lloyd.Meiosis in the leek (Allium porrum L.) revisited I. Prophase I pairing[J]. Chromosome Research .1995(7)Jones, G.H., Khazanehdari, K.A., and Ford-Lloyd, B.V. 1996. Meio- sis in the leek (Allium porrum L.) revisited. 11. Metaphase I observations. Heredity, 76: ...
SKP1-deficient oocytes exhibit desynapsis, chromosome misalignment, and progressive postnatal loss. Therefore, SKP1 maintains synapsis in meiosis of both sexes. Furthermore, our results support a model where SKP1 functions as the long-sought intrinsic metaphase competence factor to orchestrate MI entry...
Pairing of homologous chromosomes in meiosis is critical for their segregation to daughter cells. In most eukaryotes, clustering of telomeres precedes and facilitates chromosome pairing. In several species, centromeres also form pairwise associations, known as coupling, before the onset of pairing. We...
We investigated the role in meiosis of the three kinases [ATM (ataxia telangiectasia mutated), ATR (ataxia-telangiectasia- and Rad-3-related) and DNA-PKcs (DNA-dependent-protein-kinase catalytic subunit)] known to phosphorylate H2AX in mitotic cells. We found that DNA-PKcs can be ruled out ...
abnormalities or defects in oocyte meiosis can result in decreased oocyte quality, reduced ovarian reserve, and female diseases. However, the mechanisms of oocyte meiosis remain largely unknown, especially epigenetic regulation. Here, we explored the rol