A monoclonal antibody targeting a peptide that replicates the proinflammatory properties of IL-17 has shown potent activity and an acceptable profile of adverse effects in pre-clinical studies.doi:10.1038/s41584-023-01028-xRobert,PhillipsNature Reviews RheumatologyNature Publishing Group UKNature reviews. Rheumatology
IL-17A and IL-17F are prominent members of the IL-17 family of cytokines that regulates both innate and adaptive immunity. IL-17A has been implicated in chronic inflammatory and autoimmune diseases, and anti-IL-17A antibodies have shown remarkable clinical efficacy in psoriasis and psoriatic arthr...
RECENT INSIGHTS INTO THE MECHANISM OF ACTION OF 4F DIMERIC apoA-I MIMETIC PEPTIDES CLINICAL EVALUATION OF THE apoA-I MIMETIC PEPTIDE 4F ANTI-ATHEROGENIC MECHANISMS OF apoE ACTION apoE MIMETICS: A NEW DIRECTION IN PEPTIDE-BASED THERAPIES ANTI-ATHEROGENIC AND ANTI-INFLAMMATORY EFFECTS OF Ac-hE18A-NH...
Using these tools it is also possible to engineer antibodies with poor solubility or high aggregation propensity to ameliorate these characteristics20–22, although this approach can be difficult if the problematic region of the antibody resides in the paratope15. Here we describe MEDI1912, an anti...
Cellular and Molecular Life Sciences (2023) 80:189 https://doi.org/10.1007/s00018-023-04828-2 ORIGINAL ARTICLE Cellular and Molecular Life Sciences Cell targeting and immunostimulatory properties of a novel Fcγ‑receptor‑independent agonistic anti‑CD40 antibody in rhesus macaques ...
1, A–D). In contrast, enhanced interleukin (IL)-6 production was observed from leukocytes of APOE2 and APOE4 gene replacement mice similar to that observed with blood from ApoE−/− mice (Fig. 1A). Interestingly, significantly more tumor necrosis factor α (TNFα) was produced by ...
The initiation and progression of hepatocellular carcinoma (HCC) are largely dependent on its local microenvironment. Adipocytes are an important component of hepatic microenvironment in nonalcoholic fatty liver disease (NAFLD), which is a significant ri
These clusters have a higher chance of tolerating therapy and exhibit an enhanced metabolic program in response to treatment. Interestingly, the transmembrane receptor CD69 is highly expressed in chemoresistant hematopoietic stem cell (HSC)-like populations (named the CD69+ HSC-like subpopulation). ...
Colorectal cancer (CRC) is the third most commonly diagnosed cancer, which despite recent advances in treatment, remains incurable due to molecular heterogeneity of tumor cells. The B-cell lymphoma 9 (BCL9) oncogene functions as a transcriptional co-acti
These drugs are more of a palliative therapy instead of a curative. [30]. However, in June 2021 the FDA approved monoclonal antibody, aducanumab, an IgG1 anti–amyloid-β (Aβ) antibody has shown an emerging scope against AD progression [31]. In this regard, a study conducted by Jeff ...