The main functions of cartilage are to protect the subchondral bone from mechanical damage, to prevent abrasive wear between the bone extremities, and to provide low-friction bearing surfaces. Therefore, the mechanics of load transmission and the mechanical properties of cartilage influence its ability...
This chapter discusses the functions, mechanics, and mechanical properties of articular cartilage. Articular cartilage is the resilient tissue normally between 1 and 5 mm thick in humans that covers the articulating extremities of the bones at synovial joints. The main functions of cartilage are to ...
FGF-2 increased SHED's revascularization ability and boosted secretion of growth factors like VEGF and HGF, highlighting their pivotal role in enhancing MSC therapeutic functions [71]. The regulatory effect of FGF-2 on the secretion of other growth factors is suggested to occur due to the ...
A hairpin structure, referred to as the anchor, connects the OH-IH pair to the C-terminal domain (CTD) plane, which moves the OH-CED-IH-containing region of one subunit into the neighboring subunit in a clockwise direction (Figs.1and2). The anchor is made up of three helices (α1, ...
However, CXCL12 can also exert inflammatory functions, as illustrated by its pivotal role in a growing list of pathologies and its synergy with CXCL8 and other chemokines to induce leukocyte chemotaxis. Here, we review the plethora of information on the CXCL8 structure, interaction with receptors ...
Almost all of biological tissues are viscoelastic and their viscoelastic mechanical properties are important in their characteristic functions. This is because constituents of tissues cells, extracellular matrices, structural proteins, and so on are viscoelastic. Even hard tissues have ...
It is a major component of skin, bone, cartilage, tendon, blood vessels, basement membrane (endomysium), and teeth (Bandman, 1987 ; Stryer, 1988) . Collagen is a rod-shaped molecule approximately 300 nm in length and 1.5 nm in diameter. Its basic subunit is tropocollagen (mol wt 30...
Exposure to altered gravity influences cellular behaviour in cell cultures. Hydrogels are amongst the most common materials used to produce tissue-engineering scaffolds, and their mechanical properties play a crucial role in cell-matrix interaction. However, little is known about the influence of altered...
The hypergeometric function 2F1 can be written in terms of a contour integral involving gamma functions. We generalize this (Barnes) representation by usin... SNM Ruijsenaars - 《Communications in Mathematical Physics》 被引量: 93发表: 1999年 Verapamil Protects against Cartilage Degradation in Osteo...
The mechanical characterization of the articular cartilage has been widely studied in the literature due to the importance of understanding its physiological functionality. For the determination of the cartilage mechanical properties, experimental uniaxial confined and unconfined compression tests were used. Ho...