The main functions of cartilage are to protect the subchondral bone from mechanical damage, to prevent abrasive wear between the bone extremities, and to provide low-friction bearing surfaces. Therefore, the mechanics of load transmission and the mechanical properties of cartilage influence its ability...
Given the importance of Piezo channels in understanding mechanotransduction processes, this review focuses on their structural details, kinetic properties and potential functions as mechanosensors. We also briefly review the hereditary diseases caused by mutations in the Piezo genes, which is key to ...
Hydrogels have potential in a number of applications, but for many, mechanical robustness is required. Here, the authors report the preparation of a PVA/PEG hydrogel with a cartilage-inspired structure, with high compressive strength and low coefficient of friction, amongst other properties. ...
Cultivation methods and scaffolds have been developed to make cultured cartilage that has functions close to those of natural cartilage. The amount of synthesized extracellular matrix has been measured in many studies to determine the degree of maturity of regenerated cartilage in culture. Articular ...
Anti-inflammatory effect of FZ/MER-AgMOF@Bm A recent study establishes that BMSCs have an immunomodulatory effect and influence the phenotype and functions of macrophages [25]. To determine whether the nanoparticles can alter M1-like or M2-like polarization of macrophages, we used immunofluorescence...
Given the importance of Piezo channels in understanding mechanotransduction processes, this review focuses on their structural details, kinetic properties and potential functions as mechanosensors. We also briefly review the hereditary diseases caused by mutations in the Piezo genes, which is key to ...
The site-specific tissue properties of knee cartilage may play an essential role in knee joint mechanical function, and mitigate joint injury and cartilage degeneration. The present study aimed to determine the significance of tissue inhomogeneity in kne
It is a major component of skin, bone, cartilage, tendon, blood vessels, basement membrane (endomysium), and teeth (Bandman, 1987 ; Stryer, 1988) . Collagen is a rod-shaped molecule approximately 300 nm in length and 1.5 nm in diameter. Its basic subunit is tropocollagen (mol wt 300...
Gelatin is a soluble protein compound obtained by partial hydrolysis of collagen, the main fibrous protein constituent in bones, cartilages and skins; therefore, the source, age of the animal, and type of collagen, are all intrinsic factors influencing the properties of the gelatins (Johnston-Bank...
Exposure to altered gravity influences cellular behaviour in cell cultures. Hydrogels are amongst the most common materials used to produce tissue-engineering scaffolds, and their mechanical properties play a crucial role in cell-matrix interaction. Howe