Foxc2 loss‐of‐function also resulted in alterations in PlexinD1, Twist1 , PECAM1, and Hand1/2 expression in association with vascular and ventricular defects. Conclusions : Our data indicate Foxc2 is required for proper migration of cardiac neural crest cells, septation of the outflow tract...
These phenotypes derive from a combination of the failure of the posterior branchial arches to develop and the misrouting of neural crest cells. The inner ears of Tbx1 / animals are hypoplastic. No vestibular or cochlear structures are detectable, but the endolymphatic duct, the cochleovestibular ...
The cranial trigeminal ganglia play a vital role in the peripheral nervous system through their relay of sensory information from the vertebrate head to the brain. These ganglia are generated from the intermixing and coalescence of two distinct cell populations: cranial neural crest cells and pla...
Dmrt1DM domainMeiosisStra8OvaryDmrt1 belongs to the DM domain gene family of conserved sexual regulators. In the mouse Dmrt1 is expressed in the genital ridge (the gonadal primordium) in both sexes and then becomes testis-specific shortly after sex determination. The essential role of DMRT1 in...
13-P055 A factor needed for proper BMP gradient formation identified in an overexpression screen for neural crest regulators in Xenopus laevis embryosIntroduction: Administration of cadmium (Cd) after 60 h (H) incubation induces ventral body wall defect (VBWD) similar to the omphalocele phenotype ...