Tributyltin(IV) derivative (1) was synthesized by reacting the ligand (A1) {2(2﹎ethylpropanoyl)amino]propanoic acid} with tributyltin(IV)chloride in presence of potassium hydroxide. The compounds were characterized by elemental analysis, FTIR and multinuclear (1H, 13C and 119Sn) NMR ...
We have identified and synthesized a brain penetrant propanoic acid as an allosteric potentiator of the metabotropic glutamate receptor 2. Structure–activity relationship studies directed toward improving the potency, level of potentiation and brain penetration led to the discovery of 8 (EC50 = 1200 nM...
1. A process for the preparation of substantially racemic 2-{[2-(4-hydroxyphenyl)ethyl]thio}-3-[4-(2-{4-[(methylsulfonyl)oxy]phenoxy}ethyl)-phenyl]propanoic acid comprising reacting a compound of formula I enriched in one enantiomer with a chlorosilane of formula ClSiR1R2R3 in which R1,...
Chloracetic and bromacetic acids are specified as starting materials, with sodium or potassium hydroxide and zinc or aluminium. The example shows the use of chloracetic acid, sodium hydroxide and zinc dust. The product is an intermediate in the synthesis of biotin....
potassium carbonate, hydrochloric acid, saturated citric acid, potassium cyanide, ethylene diamine, EDTA, glutamic acid, saturated hydrazine, sodium hydroxide, hydroxyl amine, malonic acid, ammonia ammonium oxalate, phosphoric acid, pyridine, ammonium tartrate, potassium thiocyanate, triethanolamic have been...
esterifying pure compound of formula (9b) defined above using alkylating agent in the presence of potassium carbonate,hydrochloric acid, sulfuric acid, amberlite or amberlist to produce .pure compound of formula (9c). acid or acidic resin to yield purecompound of formula (9c) where R1 ...