it is a competitive histamine H1-receptor antagonist and blocks most, but not all, of the pharmacologic effects of histamine mediated at H1-receptors. The clinical effects of promethazine are evident within 5 minutes of intravenous administration. Its duration of action is 4 to 6 hours and plasma...
Duration of action is four to six hours, effects may persist up to 12 h. Promethazine hydrochloride is metabolised in the liver. We cannot obtain commercially prepared promethazine injection in our country.doi:10.1136/ejhpharm-2015-000639.302E. Najdovska...
• Promethazine hydrochloride is given in doses of 20 to 50 mg at night for the short-term management of insomnia although its prolonged duration of action can lead to considerable drowsiness the following day. • For the prevention of motion sickness promethazine hydrochloride can be given in...
Additional doses may be given on arising in the morning and before the evening meal for the duration of the journey.Common ColdFor the temporary relief of rhinorrhea or sneezing associated with the common cold in adults and children 12 years of age and older, an oral promethazine hydrochloride...
Dextromethorphan is rapidly absorbed from the gastrointestinal tract and exerts its effect in 15 to 30 minutes. The duration of action after oral administration is approximately three to six hours. Dextromethorphan is metabolized primarily by liver enzymes undergoing 0-demethylation, N-demethylation, and...
Because the duration of opioid reversal is expected to be less than the duration of action of codeine in Promethazine with Codeine Oral Solution, carefully monitor the patient until spontaneous respiration is reliably reestablished. If the response to an opioid antagonist is suboptimal or only brief...
Duration: PO (motion sickness), 4-6 hr; IV (nausea and vomiting), 4-6 hr; up to 12 hr Distribution Protein bound: 93% Vd: 98 L/kg (syrup); 17-277 L/kg (range) Metabolism Metabolized by hepatic P450 enzyme CYP2D6 Metabolites: Promethazine sulfoxide and glucuronides (inactive) Elimina...
The dose and duration of therapy is determined by the indication. Some chronic allergy sufferers require long-term antihistamine throughout the allergy season. In the case of pre-operative sedation, a single dose may be used. For motion sickness, the drug should be taken only while traveling....
(promethazine hydrochloride syrup plain) Plain during labor and delivery does not have an appreciable effect on the duration of labor or delivery and does not increase the risk of need for intervention in the newborn. The effect on later growth and development of the newborn is unknown. (See...
Moderate doses of promethazine (5 and 10 mg kg鈭 1) potentiated morphine's action in male mice but inhibited it in female mice. Gonadectomy abolished the interaction between promethazine and morphine in both sexes, although the intensity and duration of morphine's activity was greatly enhanced ...