Mutations of proline-rich transmembrane protein 2 (PRRT2) lead to dyskinetic and convulsive disorders such as paroxysmal kinesigenic dyskinesia (PKD), benign familial infantile seizure and hemiplegic migraine.
Proline-rich transmembrane protein 2 (PRRT2) is located on chromosome 16p11.2 and encodes for a 340 amino acids protein (proline-rich transmembrane protein 2) expressed highly in the cortex and the cerebellum (Landolfi et al., 2021). This protein was first described to interact with 25 kDa...
Proline-Rich Synapse-Associated Protein 2 proline-rich transcript in brain proline-rich transcript, brain-expressed protein proline-rich transcription factor ALX3 proline-rich transmembrane protein 1 proline-rich transmembrane protein 2 proline-rich transmembrane protein 3 ▼Face...
Expression Regulation, Protein Chemistry and Functional Biology of the Guanine-Rich Sequence Binding Factor 1 (GRSF1)J. Mol. Biol. (IF 4.7)Bernhard Dumoulin, Christoph Ufer, Hartmut Kuhn, Sajad Sofi Pub Date: 2021-03-10 N-terminal Domains of DELLA Proteins Are Intrinsically Unstructured in the...
Since the discovery in the early 1990s that the SH3 (Src homology 3) domains of Abelson tyrosine kinase (Abl) and Src interact directly with polyproline motifs 1., 2., proline-rich sequences have emerged as important mediators of protein–protein interactions. Well-characterized polyproline-b...
Tissue architecture contributes to pancreatic ductal adenocarcinoma (PDAC) phenotypes. Cancer cells within PDAC form gland-like structures embedded in a collagen-rich meshwork where nutrients and oxygen are scarce. Altered metabolism is needed for tumour
Proline-rich extension-like receptor protein kinases (PERKs) are an important class of receptor kinases located in the plasma membrane, most of which play a vital role in pollen development. Our study identified 25 putative PERK genes from the whole Bras
The sequence of the EfpL protein (NP_416676.4) from E. coli str. K-12 substr. MG1655 has an extended β3Ωβ4 loop SPTARGAAT with the R residue at the tip. The phylogenetic tree was annotated according to the length of the β3Ωβ4 loop and the nature of the residue at the tip...
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As a transmembrane protein, CD44 is synthesized in the ER and traffics to the cell surface. CD44v, a variant isoform of CD44 containing variable exon 3 to 10 that is abundantly expressed in the MCF7-LR cells, was detected in the cytosolic and perinuclear region as well as inside the ...