Graphical abstract In search of new ways to improve catalyst design, the current research focused on using quantum mechanical descriptors to investigate the effect of proline as a catalyst for mechanism and rate of asymmetric aldol reaction. A plausible mechanism of reaction between acetone and 4-...
Lessons learnt from the aldolase antibodies, the Hajos–Parrish–Eder–Sauer–Wiechert reaction, and the discovery of non-proteinogenic, metal complex-catalyzed direct asymmetric aldol reactions,30 led to the development of the first proline-catalyzed direct asymmetric aldol reaction.31 Initially, it ...
Long He,Zhuo Tang,Lin-Feng Cun,Ai-Qiao Mi,Yao-Zhong Jiang,Liu-Zhu Gong.l -Proline amide-catalyzed direct asymmetric aldol reaction of aldehydes with chloroacetone[J]. Tetrahedron .2005(2)Long He,Zhou Tang,Lin-Feng Cun et al.L-Proline amide-catalyzed direct asymmetric aldol reaction of ...
Asymmetric aldol reaction catalyzed by new recyclable polystyrene-supported l-proline in the presence of water. Liu, Yu-Xia,Sun, Ya-Nan,Tan, Hao-Han,Tao, Jing-Chao. Catalysis Letters . 2008Liu Yu Xia,Sun Ya Nan,Tan Hao Han,et al.Asymmetric aldol reaction catalyzed by new recyclable ...
L・ ・ proline・ ・ catalyzedasymmetric aldol reaction,these two compoundsshouldhavethesame configuration at C-2,andhencetheabsolute configurationofthe major diastereomerof19hshould be(2R,as).Considering themechanistic similarity,inallreactions,themajor andtheminordiastereomerswereconsideredas of(2...
direct asymmetric aldol reactionL-prolinepolyethylene glycolA simple and efficient composite catalyst of L-proline–polyethyleneglycol(PEG)–SiO2 was developed for the asymmetric aldol reaction between acetone and p-nitrobenzaldehyde. With 10mol% L-proline, the composite catalyst showed much better ...
Ring—ClosingMetathesis(RCM)reactionasthe keystepandL—proline—catalyzed asymmetric Aldolreactionsof protectedhydroxyacetone.At thesalnetime,wehave developednovelmacrocyclizationmethodsofcembrene—typediterpenoidsemploying theringclosingmetathesis(RCM)reactionandlow-titanium—inducedintramolecular ...
direct asymmetric aldol reactionpolyethylene glycolA simple and efficient composite catalyst of L-proline–polyethyleneglycol(PEG)–SiO2 was developed for the asymmetric aldol reaction between acetone and p-nitrobenzaldehyde. With 10 mol% L-proline, the composite catalyst showed much better yield and...
A convenient method for proline-catalyzed asymmetric aldol reactions using synthons of straight-chain aliphatic aldehydes, and aldehydes bearing a 1,3-dithiane moiety at the beta-position, has been developed. This method was successfully applied to the synthesis of (5R,6S)-6-acetoxyhexadecanolide,...
High-Pressure-Promoted Asymmetric Aldol Reactions of Ketones with Aldehydes Catalyzed by L-Proline. Synlett 2003 - Sekiguchi, Sasaoka, et al.Sekiguchi YAR, Sasaoka A, Shimomoto A, Fujioka S, Kotsuki H. High-pressure-promoted asymmetric aldol r eactions of ketones with aldehydes catalyzed by L-...