However, little is known about the specific function ofin carcinogenesis and malignant progression. To better our understanding of the function ofin prostate cancer, we used siRNAs to examine the effects ofknockdown on cell proliferation and the cell cycle. In addition, the relation between ...
Changes in regulatory feedback loops for growth factors with prostate cancer progression tend toward shifts from paracrine to autocrine control where the receptor and ligand are produced by the same cell. While there are several examples of this progression pattern in prostate tumors such as with ...
Of note, overexpression of RBMS3-AS3 was found to suppress cell proliferation, migration, invasion, and angiogenesis as well as the tumorigenic ability of prostate cancer. VASH1 was verified as a target gene of miR-4534. VASH1 expression was found to be downregulated in prostate cancer tissues...
Introduction of the prostate specific antigen (PSA) serum marker for prostate cancer and the subsequent PSA era from 1988 to the present have dramatically altered the diagnosis of the disease. The early to mid 1990s diagnosis boom resulted in a huge increase in clinically localized and early stage...
The cellular alterations that give rise to cancer initiate changes in cytokine expression. Though IL-6 is known to play a major role in proliferation of tumor cells, IL-4 upregulates androgen receptors and prostate-specific antigen (PSA). The present study was undertaken to evaluate the associati...
Critical Role of O-Linked β-N-Acetylglucosamine Transferase in Prostate Cancer Invasion, Angiogenesis, and Metastasis Cancer cells universally increase glucose and glutamine consumption, leading to the altered metabolic state known as the Warburg effect; one metabolic path... TP Lynch,CM Ferrer,SR ...
Prostate disease, either symptomatic benign prostatic hyperplasia (BPH) or cancer, is a significant health problem. The estimated prevalence of symptomatic BPH from community-based studies is 40% for men in their 70s, and histological evidence of BPH in autopsy studies is found in 60%–80% of ...
INTEGRATIVE BIOLOGY OF PROSTATE CANCER PROGRESSION 青云英语翻译 请在下面的文本框内输入文字,然后点击开始翻译按钮进行翻译,如果您看不到结果,请重新翻译! 翻译结果1翻译结果2翻译结果3翻译结果4翻译结果5 翻译结果1复制译文编辑译文朗读译文返回顶部 综合生物学前列腺癌的进展...
Prostate cancer is the most commonly diagnosed cancer and the leading cause of cancer death among men in the United States. Cancer is a polygenic disease. Intensive investigations during last decades have led to identify more gene mutations and chromosomal abnormalities associated with human prostate ...
Heterogeneity of genetic changes was frequently observed among multiple cancer foci. Lymph node metastases of prostate cancer usually shared genetic changes with paired primary tumors. In addition, the genetic change pattern with 8p, +c-myc or AI-c-myc, +7q, and +p53 was slightly higher in ...