The majority, 80%–90%, of lung cancers are caused by tobacco smoking and thus are preventable. The biology of lung cancer results in symptoms after the disease is significantly advanced — and metastatic — and, as a consequence, 90% of patients die of their disease within 1–2 years....
Despite advances in diagnosis, staging, surgical techniques, and neoadjuvant chemoradiotherapy over the last decade, the mortality rate of lung cancer is still high and 5-year survival is only 15% (Siegelet al.,2012a;2012b). As a result of a lack of early specific signs and symptoms, most...
craig2097over a year ago Hi, I must say that it is a pity she didn’t notice it before, while she could prevent spreading of the cancer by therapy or even if necessary removing the infected to prevent any new malignant occurrence. The metastatic activity of a tumor, increases with both ...
Xue T, Chen Y, Xu J et al (2023) Cyclovirobuxine D inhibits growth and progression of non-small cell lung cancer cells by suppressing the KIF11-CDC25C-CDK1-CyclinB1 G2/M phase transition regulatory network and the NFκB/JNK signaling pathway. Int J Oncol 62:57. https://doi.org/...
Cancer is among the leading causes of death related diseases worldwide, and lung cancer has the highest mortality rate in the world. Transcription factors (TFs) constitute a class of structurally and functionally intricate proteins. Aberrant expression o
Small cell lung carcinoma (SCLC) accounts for 15–20% of all lung cancers and is the most aggressive lung-cancer subtype. Even with treatment median overall survival is short, in the range of 9–12 months. Tobacco smoking is the main risk factor with nearly 95% of the cases being linked...
The study explores Artificial Intelligence (AI) powered modeling to predict the evolution of cancer tumor cells in mice under different forms of treatment. The AI models are analyzed against varying ambient and systemic parameters, e.g. drug dosage, volume of the cancer cell mass, and time taken...
et al. Targeted genetic dependency screen facilitates identification of actionable mutations in FGFR4, MAP3K9, and PAK5 in lung cancer. Proc. Natl Acad. Sci. USA (2013). This paper gives an analysis of potential gain-of-function mutations in PAK5 in lung cancer. Shrestha, Y. et al. ...
[2]. The insidious symptoms of early lung cancer lead to the loss of surgical opportunities at initial diagnosis, and therefore, chemotherapy alone or in combination with radiotherapy has been adopted as the main treatment method for patients with advanced lung cancer [3]. Currently, the 5-year...
I had my routine scans last Friday. Afterward I texted Alice to let her know I was certain they would show progression, based on my physical symptoms. My scan review was to be this Thursday with my nurse practitioner rather than Alice and I wanted to make certain the two of them talked...