patients with malignant nodules. we also asked experts to indicate their level of agreement with assumptions about tumor growth rates, disease progression, and survival by using a 5-point likert scale . we developed survey items based on assumptions from a natural history model of lung cancer. 7...
Recently, great strides have been made in immunotherapies, which appear to be finally coming of age and are showing great promise for advancements in cancer survival. However, the relative efficacy of immunotherapy has been greater as an adjuvant in treating patients with operable disease at hig...
Significantly high-expressed circFLNA has been found in various cancer cell lines, but not in lung cancer. Therefore, this study aimed to explore the role of circFLNA in the progression of lung cancer. The target gene of circFLNA was determined by bioinformatics and luciferase reporter assay. V...
to differentiate into cancer cells and a variety of stromal cells, maintaining the csc microenvironment to promote csc properties and tumour development. cscs can differentiate into cancer cells, which has been validated in other types of cancers, including pancreatic, prostate, lung and liver cancer...
Advanced lung cancerVascular targeted therapyRecent efficacyDrug safetyObjective:To analyze the clinical efficacy,progression-free survival,and safety of anlotinib in the treatment of advanced lung cancer.Methods:A retrospective analysis was conducted using data from 60 patients with advanced lung cancer ...
Multitrial Evaluation of Progression-Free Survival as a Surrogate End Point for Overall Survival in First-Line Extensive-Stage Small-Cell Lung Cancer Introduction: We previously reported that progression-free survival (PFS) may be a candidate surrogate end point for overall survival (OS) in first-...
At Baptist Health Miami Cancer Institute, we performed a retrospective study to determine the impact of the COVID-19 pandemic on potential stage migration of melanoma, breast cancer, and colorectal cancer. We analyzed 2168 patients, comparing clinical and pathological diagnosis staging values for the...
2 The prognosis for liver cancer is unfavorable, showed by the 10.1% of age-standardized 5-year relative survival in China.3 In the present review, we will focus on the most common histologic type of liver cancers-hepatocellular carcinoma (HCC), which represents 85–90% of primary liver ...
activity of DNA-PKcs in PBLs was generally decreased in patients with advanced cancer, which was correlated with an invasive phenotype and a poor prognosis. Auckland et al. [58] reported that the decrease in DNA-PKcs in peripheral monocytes was associated with the development of lung cancer. ...
Response ratesResponse criteria have always been difficult to apply to malignant pleural mesothelioma (MPM), due to its unique pattern of growth. We developed some models to show that progression free survival rate (PFSR) could be a better predictor of overall survival (OS) than the response ...