HEART metabolismBackground: Previous studies in dogs with degenerative mitral valve disease (DMVD) have identified altered myocardial energy metabolism and oxidation, which might contribute to cardiac hypertrophy. Diets rich in medium chain fatty acids and antioxidants are a potential means o...
Ionic Mechanism of Action Potential Prolongation in Ventricular Myocytes From Dogs With Pacing-Induced Heart Failure Membrane current abnormalities have been described in human heart failure. To determine whether similar current changes are observed in a large animal mode... S Kääb,HB Nuss,N ...
Indoxyl sulfate: a novel cardiovascular risk factor in chronic kidney disease[J]. J Am Heart Assoc,2017,6(2):e005022. DOI: 10.1161/JAHA.116.005022. [10] Ito S,Yoshida M. Protein-bound uremic toxins: new culprits of cardiovascular events in chronic kidney disease patients[J]. Toxins,...
To investigate the efficacy of the peroxisome proliferator-activated receptor-α (PPARα) agonist, AVE8134, in cellular and experimental models of cardiac dysfunction and heart failure. Methods: In Sprague Dawley rats with permanent ligation of the left coronary artery (post-MI), AVE8134 was compar...
Controlled Clinical Evaluation of Enalapril in Dogs With Heart Failure: Results of the Cooperative Veterinary Enalapril Study Group The COVE Study Group The clinical efficacy and safety of enalapril were evaluated in dogs with moderate or severe heart failure. This study was conducted at 19 centers ...
- 《European Heart Journal》 被引量: 96发表: 2009年 Use of signal analysis of heart sounds and murmurs to assess severity of mitral valve regurgitation attributable to myxomatous mitral valve disease in dogs To investigate use of signal analysis of heart sounds and murmurs in assessing severity ...
derivatives. mRNA expression of IL-1β in the heart was significantly lower in rats given FR167653. However, mRNA of TNF-α was not detected in any groups. Our results suggest that FR167653 suppresses the development of myocarditis by suppression of IL-1β. (Mol Cell Biochem246: 39-44,...
Alpacas, like all camelids, have elliptical red blood cells (RBCs) in contrast to other mammals. This particular shape is important for increased osmotic resistance and stability. Age-related changes in the RBC count are known in other species, with alte
4 A variety of similar considerations suggest that the pathogenesis of vascular disease in CKD is substantially more complex and effective cardiovascular risk reduction would require us to also target nontraditional, renal-related risk factors. A substantial body of evidence implicates abnormal phosphorus ...
important because in the current clinical trials children with CLN2 disease are being treated with administration of recombinant TPP1 only to the CNS. To evaluate the possibility that these children may eventually exhibit extraneuronal pathology,TPP1−/−dogs with delayed CLN2 disease progression ...