In peripheral blood mononuclear cells of non-smoking individuals, non-obstructive smokers, patients with COPD of all stages and those with COPD exacerbation, we evaluated DNA damage, PARP activity and PARP-1 mRNA expression using Comet Assay IV, biotinylated-NAD incorporation assay and qRT-PCR, ...
Exercise training has been shown to be beneficial at all stages of COPD. Mobility of the chest wall influences lung function. We hypothesise that the application to 'at risk' individuals (stage 0) of therapeutic interventions known to improve chronic respiratory symptoms and cardiovascular function ...
Results Smoking cessation reduced lung function decline at all stages of COPD, and the earlier the intervention, the greater the impact on lung function. Accumulating data from placebo-controlled trials suggested that long-acting bronchodilators can slow the decline in lung function, as well as ...
Progression of COPD is marked by increased serverity and duration of symptoms, until, during advanced stages, the patient experiences constant wheezing and shortness of breath, with a severe cough even while at rest. COPD advances either rapidly or slowly; rapid decliners, as shown in FIG. 1,...
There is limited evidence regarding the causal inference of emphysema and functional small airway disease in the subsequent progression of chronic obstructive pulmonary disease (COPD). Patients consisting of two independent cohorts diagnosed with COPD an
The FST has been proposed as a reliable indicator for predicting the progression of AKI to severe AKI or the need for RRT in the early stages of AKI [21, 22]. Nonetheless, concerns have been raised regarding potential adverse effects associated with FST, such as hypovolemia, which restricts ...
The diagnosis of HFpEF is complex, also because of the multiple cardiac and non-cardiac comorbidities associated with the disease, such as atrial fibrillation, diabetes, chronic obstructive pulmonary disease (COPD), and renal dysfunction. These comorbidities may be a cause, contributing factor for dev...
"Severe acute respiratory disease events may be a sign of disease activity and a source of morbidity at the earliest stages of lung tissue injury," she said. "Some people with QIA progression may merit more aggressive monitoring and earlier intervention." ...
Inflammation is considered to be of primary pathogenic importance in COPD but the evidence on which current understanding is based does not distinguish between cause and effect, and no single mechanism can account for the complex pathology. We performed a prospective longitudinal study of subjects with...
3a). Sorted ILC2s were then transferred into Rag1−/− mice (CD45.2/2), who were in initial fibrogenesis stages (week 4). ILCs, readily identifiable by CD45.1 expression, infiltrated recipient Rag1−/− mouse lungs (Supplementary Fig. 3b). Sorted ILC2s were ST-2+ and NKp46– ...