The stress-activated protein kinase p38 phosphorylates p57/Kip2, resulting in enhanced CDK2 inhibition and a cell-cycle delay that helps cells to survive under stress. The p57Kip2cyclin-dependent kinase inhibitor (CDKi) has been implicated in embryogenesis, stem-cell senescence and pathologies, but...
The interrelationship between commitment (irreversible withdrawal from the cell cycle) and muscle-specific gene expression was analyzed with the myogenic c... HT Nguyen,RM Medford,B Nadal-Ginard - 《Cell》 被引量: 246发表: 1983年 Reversibility of symptoms in a conditional mouse model of spinocereb...
C. l-arginine availability regulates T-lymphocyte cell-cycle progression. Blood 109, 1568–1573 (2006). Article PubMed CAS Google Scholar Salimu, J. et al. Dominant immunosuppression of dendritic cell function by prostate-cancer-derived exosomes. J. Extracell. Vesicles 6, 1368823 (2017). Hsu...
It seemed that USP27 was also transcriptionally regulated in the cell cycle progression (Figure S2D). Interestingly, USP27 expression might also be regulated by Fbxw7, a well-known E3 ubiquitin ligase of Cyclin E, which interacts with and degrades USP27 (Figure S3A–C). Next, we ...
Objective: Our aim was to determine the effect of toad toxication on proliferation and progression of cell cycle in cultured leukemia K562 cells. Methods:The secretion of sebaceous gland of Chinese toad was soaked with etha-nol, DMSO, and PBS. Three kinds of crude extraction (extraction E, D...
Regulation of the cdc25 protein during the cell cycle in Xenopus extracts. The cdc25 protein is a highly specific tyrosine phosphatase that triggers mitosis by dephosphorylating the cdc2 protein kinase. Using Xenopus extracts, we ... A Kumagai,WG Dunphy - 《Cell》 被引量: 767发表: 1992年 ...
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Using these criteria, only 1,927 genes of the 2,833 cell cycle regulated genes are included in the gene sets. These criteria allowed us to generate gene sets for GSEA within the recommended size limits, between 15 and 500 genes. Figure 1A illustrates sizes of the generated gene sets for ...
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These metabolites could serve as a carbon and nitrogen source, feeding into the cancer cells’ tricarboxylic acid (TCA) cycle. A predicted lower net production of lactate in HT-29 cells, together with a reduced gene expression of glycolysis enzymes and lower levels of lactate detected in the ...