The focus of cancer immunotherapy has traditionally been on immune cells and tumor cells themselves, often overlooking the tumor secretome. This review provides a comprehensive overview of the intricate relatio
Furthermore, the NLRP3 inflammasome is significant in pyroptosis, a form of cell death closely linked to proinflammatory responses, which primarily occurs in myeloid lineage cells, specifically professional phagocytes such as macrophages and neutrophils. After SCI, DAMP recruit pro-caspase-1 through act...
Jun 2023;5(1):59. Article Google Scholar Grobben Y. Targeting amino acid-metabolizing enzymes for cancer immunotherapy. Front Immunol 2024;Aug 14;15, 1440269. Wang R, Dillon CP, Shi LZ, Milasta S, Carter R, Finkelstein D et al. The transcription factor Myc controls metabolic ...
Urine leucine-rich alpha-2 glycoprotein 1 (LRG1) predicts the risk of progression to end-stage kidney disease in patients with type 2 diabetes. Diabetes Care. 2023;46(2):408–15. Article CAS PubMed Google Scholar Johansen KL, Chertow GM, Foley RN, Gilbertson DT, Herzog CA, Ishani A,...
We identified and validated TMEM41B as a target of miR-660-5p in breast cancer cells, which aligns with previous findings that miR-660-5p promotes breast cancer progression by targeting TET2 and activating the PI3K/AKT/mTOR pathway [14] and the miR-660-5p/TFCP2/CDKN1A pathway [13]. ...
Accumulating evidence demonstrates that the activity regulation of ELK3, a member of the E26 transformation-specific oncogene family, is critical to regulating cell proliferation, migration, and survival in human cancers. However, the molecular mechanism
Eye and Vision volume 11, Article number: 1 (2024) Cite this article 2100 Accesses 2 Altmetric Metrics details Abstract Background To assess repeatability and reproducibility of corneal epithelium thickness (ET) measured by a spectral-domain optical coherence tomographer (SD-OCT)/Placido topographer...
2024;127: 155496. Article PubMed CAS Google Scholar Chen H, Tong T, Lu SY, Ji L, Xuan B, Zhao G, Yan Y, Song L, Zhao L, Xie Y, et al. Urea cycle activation triggered by host-microbiota maladaptation driving colorectal tumorigenesis. Cell Metab. 2023;35(4):651-66.e7. Article...
Journal of Cancer Research and Clinical Oncology (2024) Preliminary results from the EMoLung clinical study showing early lung cancer detection by the LC score Karla Rubio Jason M. Müller Guillermo Barreto Discover Oncology (2023) RETRACTED ARTICLE: Long non-coding RNA GATA6-AS1 upregulates GAT...
Heart failure with preserved ejection fraction (HFpEF) is associated with systemic inflammation, obesity, metabolic syndrome, and gut microbiome changes. Increased trimethylamine-N-oxide (TMAO) levels are predictive for mortality in HFpEF. The TMAO precu