prognosistumour immune microenvironmentLow-grade glioma (LGG) is a heterogeneous tumour with the median survival rate less than 10years. Therefore, it is urgent to develop efficient immunotherapy strategies of LGG. In this study, we analysed mutation profiles based on the data of 510 LGG patients ...
Lower-grade gliomas (LGGs) are defined as World Health Organization (WHO) grades II and III gliomas, including diffuse low-grade and intermediate-grade gliomas, accounting for approximately 20% of glioma cases7. LGG has a relative better survival compared with high grade glioma, with an average...
In recent years, despite the fact that several gene signatures have been established for predicting the prognosis of glioma patients24,25,26, none of them was associated with PANoptosis. Moreover, samples were simply separated into low or high-risk groups with distinct prognosis based on the spec...
Significant advancements in neurosurgical planning, approach, and practice over the past five decades have improved the surgical management of diffuse low and high-grade gliomas. We sought to evaluate the extent to which LGG survival outcomes have evolved over the past fifty years using glioma ...
Low-grade glioma (LGG) is a primary, slow-growing brain tumor; however, its treatment and prognosis remain challenging. In this study, we analyzed cancer data from the TCGA database, focusing particularly on the expression of the CDKN3 gene in LGG. The results showed that high CDKN3 ...
Tumour microenvironment of brain lower grade glioma (LGG) consists of non‐tumour cells including stromal cells and immune cells mainly. These non‐tumour cells dilute the purity of LGG and play pivotal roles in tumour growth and development, thereby affecting patient prognosis. Tumour purity is ...
The results demonstrated that APLN and APLNR mRNA expression were significantly increased in CNS cancers, including both low-grade glioma (LGG) and glioblastoma (GBM), when compared with normal CNS tissues. The high APLN, but not APLNR, expression was significantly correlated with overall survival ...
The World Health Organization (WHO) classification of CNS tumors classifies gliomas into low-grade gliomas (LGGs; WHO I–II) and high-grade gliomas (HGGs; WHO III–IV) by classical histological and molecular characteristics [2]. The survival time after diagnosis of glioma varies among the ...
Glioma is the most common primary malignant brain tumor. Despite significant advances in the past decade in understanding the molecular pathogenesis of thi
(E) The number of times each genes was screened out by the machine learning framework in TCGA-Glioma cohort and TCGA-GBM cohort. (F) The profile of the SLC43A3 in different grade glioma and normal brain cortex tissues in TCGA and GTEx datasets. Wilcoxon rank sum test was used for ...