PROFILE 1014是首个III期随机对照临床试验,前瞻性地对比了克唑替尼与铂类联合培美曲塞化疗方案在ALK阳性NSCLC患者(包括稳定、治疗过的脑转移患者)中的CNS疗效。总的来说,PROFILE 1014为我们提供了关于伴有CNS转移患者的最佳一线治疗决策的有用信息,并使我们放心于应用克唑替尼治疗此类患者及其局部疗效(图1);也强调了...
Clinical trial identification: NCT01154140 Legal entity responsible for the study: Pfizer Funding: Pfizer Disclosure: T.S.K. Mok: Honoraria from AstraZeneca, Roche/Genentech, Eli Lilly and Co., Bristol-Myers Squibb Co., Boehringer Ingelheim, Novartis Pharmaceuticals, MSD, and Pfizer, fees for se...
[8] Kim DW, Mehra R, Tan DS, et al. Activity and safety of ceritinib in patients with ALK-rearranged non-small- cell lung cancer (ASCEND-1): updated results fromthe multicentre, open-label, phase 1 trial. Lancet Oncol 2016;17:452-63. [9] Solomon BJ, Cappuzzo F, Felip E, et al...
Purpose The phase III PROFILE 1014 trial compared crizotinib with chemotherapy as first-line treatment in patients with anaplastic lymphoma kinase (ALK) -positive advanced nonsquamous non-small-cell lung cancer. Here, we report the final... Solomon, Benjamin J.,Kim, Dong-Wan,Wu, Yi-Long,......
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This randomized controlled trial aimed to investigate the effects of a 6-month home-based exercise training programme on functional capacity, glucose levels and lipid profile of diabetic KT patients. METHOD A total of 21 type II diabetic KT recipients were randomly assigned into two groups: ...
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(i.e., trial profile parameters) for a hypothetical profile. If the measured diffraction signal and the simulated diffraction signal do not match or when the difference of the measured diffraction signal and one of the simulated diffraction signals is not within a preset or matching criterion, ...