Here, we report structure-function studies of the N-terminal peptide from mouse, human, and rat profilaggrin. The profilaggrin N- terminal peptides of all species contain two S100-like EF-hands, bipartite nuclear localization sequences, and proprotein convertase cleavage sites. The nuclear ...
, 2009). The precise function of the C-terminal domain is unclear, but it is known to be required for the processing of profilaggrin to filaggrin. Loss-of-function mutations within FLG exon 3 result in a truncated profilaggrin molecule, which lacks the C terminus, resulting in an almost ...
The function of this region is not known but has recently been postulated to be involved in triggering nuclear events associated with the final stages of epidermal differentiation (Ishida-Yamamoto et al, 1998;Presland and Dale, 2000). The C-terminal of profilaggrin contains a distinct hydrophobic...
We report here advances in the molecular structure and biochemical function of the N-terminus of human profilaggrin. First, we determined the 2.2 Å resolution x-ray crystal structure of the S100 fused-type CABD of profilaggrin. Second, several biochemical and yeast two-hybrid (Y2H) studies ...
Most likely the AP1 site-independent transactivation by c-Jun and JunD both in F9 and HeLa cells reflected the modulatory effect of the Jun proteins on the function of transcriptional regulators operating downstream from the AP1 motif (see below). In HeLa cells the forced expression of JunB ...
Toperform this role, epithelial keratinocytes undergo awell-defined differentiation program that results intheexpression of structural proteins which maintain theintegrity ofepithelial tissues andfunction asaprotective barrier. This review focuses onstruc- tural proteins......
Epithelial tissues function toprotect theorganism fromphysical, chemical, andmicrobial damage andareessential for survival. Toperform this role, epithelial keratinocytes undergo awell-defined differentiation program that results intheexpression of structural proteins which maintain theintegrity ofepithelial ...
Filaggrin Gene Polymorphism Pro478Ser, but Not Loss-of-Function Mutations Mp.Arg501Ter or C.2282del4, Relates with Atopic Dermatitis Severity and Increased Staphylococcal aureus Colonization in Adult PatientsFreshwater live fishEnergy conservation and emission reduction (ECER...