Critical Care (2023) 27:276 https://doi.org/10.1186/s13054-023-04556-w Critical Care BRIEF REPORT Open Access Evaluation of Proenkephalin A 119–159 for liberation from renal replacement therapy: an external, multicenter pilot study in critically ill patients with acute kidney ...
(PENK).65Thispeptide fragment'slevels in plasma/serum could serve as a surrogate measurement of systemic enkephalin synthesis, because proenkephalin is the predominant source of mature enkephalins. For the remainder of this article,PENKrefers to the measurement of proenkephalin 119-159 using this ...
Forest plots of a multivariable analysis shows odds ratio for clinical variables, natriuretic peptides, and amino acids 119 to 159 of proenkephalin A for prediction of worsening renal function (WRF) during initial hospitalization. ACE = angiotensin-converting enzyme; ARB = angiotensin receptor blocker...
Background Proenkephalin A 119-159 (penKid) has been suggested as a marker of renal failure and poor outcome. We aimed to investigate the association of penKid on ICU admission with organ dysfunction and mortality in a mixed ICU population. In this retrospective, observational study, admission ...
The novel blood biomarkers proenkephalin A 119-159 (penKid), bioactive adrenomedullin (bio-ADM) and circulating dipeptidyl peptidase 3 (cDPP3) have not been previously investigated for the early prognosis of cardiac arrest survivors.Thorgeirsdottir, BergthoraLevin, HelenaSpangfors, MartinAnnborn, ...
In Vitro Assessment of Proenkephalin a 119-159 (PenKid) Removal in Hemofiltration, Hemodialysis, and Hemoadsorptiondoi:10.1681/ASN.2024h4nnfbtvAnna LorenzinDepartment of Nephrology, Dialysis and Transplantation, St. Bortolo Hospital, Vicenza, Italy;...
Proenkephalin A 119-159 as a Novel Biomarker for Early Detection of Delayed Graft Function After Kidney Transplantationdoi:10.1681/ASN.20233411S147cChristian NusshagHeidelberg University Hospital Department of Nephrology, Heidelberg, Germany;Louise Benning...
Proenkephalin A 119-159 (penKid) is a stable surrogate marker for enkephalins (endogenous opioids regulating kidney function). Different clinical studies have shown severity-dependent increased penKid levels in patients with sepsis-associated acute kidney injury (AKI), indicating that penKid can be ...
Delayed graft function (DGF) frequently occurs following kidney transplantation, and prolonged duration of DGF adversely affects 1-year graft function and long-term graft survival. Recently, Proenkephalin A 119-159 (penKid) was shown to reflect kidney function and predict acute kidney injury (AKI)...
Proenkephalin a 119–159 (penKid) – a novel biomarker for acute kidney injury in sepsis: an observational studyPro-enkephalinpenKidSepsisAcute kidney injuryEmergency departmentAKIStudy population characteristics. Presented in amounts (percentages of total) or median value (interquartile range)...