In this publication, we provide a thorough review of the literature on AMF mediation of secondary metabolites production in medicinal plants. We also review the different methods that are used to increase/stabi
pathways of major plant secondary metabolites such as alkaloids, terpenoids and flavonoids with notes on their target genes and their biosynthetic products, kinds of regulatory miRNAs with their respective regulatory roles and methods of detection with a note on the future direction of relevant research...
Zhgun AA. Fungal BGCs for production of secondary metabolites: main types, central roles in strain improvement, and regulation according to the piano principle. Int J Mol Sci. 2023;24(13):11184.https://doi.org/10.3390/ijms241311184. ArticleCASPubMedPubMed CentralGoogle Scholar Qin X, Su X,...
Although reported to be successful in prokaryotes like actinomycetes6,7 and eukaryotes such as baker’s yeast8,9,10 and filamentous fungi11,12, yields of heterologous secondary metabolites can vary substantially from the natural producer. Moreover, the native BGC-related product fingerprint of the ...
2a). The 3D PCA score scatter plot show that C, D2, D3 and D4 are closely clustered indicating that adding diaper waste leads to the production of secondary metabolites similar to the control (Fig. 2b). The stacking spectra of D2 being the most efficient growth substrate show no extra...
First, most PNPs are secondary metabolites, which receive relatively low levels of carbon metabolic flux in comparison with primary metabolites. Thus, it is necessary to rewire the metabolic fluxes toward their precursors in order to increase the production of PNPs. Second, due to the complexity ...
Plants subjected to wounding stress produce secondary metabolites. Several of these metabolites prevent chronic diseases and can be used as colorants, flavors and as antimicrobials. This wound-induced production of plant secondary metabolites is mediated
Various effects of mycoviruses on fungal hosts have been observed. For instance, some mycoviruses can hinder fungal growth (Li et al. 2019), while others can reduce the secretion of secondary metabolites (Liu et al. 2022), and some can even transform host fungi into endophytes, promoting the...
studies have suggested that elicitation is an effective strategy to increase the production of secondary metabolites in plants. This could help overcome the limitations of plant cell technology for commercial use. An external stimulus may enhance the synthesis of secondary metabolites by triggering various...
A possible explanation is that eftu and sod promoters are not applicable in the production of secondary metabolites in C. glutamicum. Given that the transcript threshold of ANS and 3GT tolerated by the host cells may be much lower than that of the pathway genes in amino acid biosynthesis, ...