Given the semi-solid and highly dynamic nature of bone marrow, it has so far been difficult both to tell how cells are organized in the tissue, and to resolve the production of blood cells at a single-cell level. Writing in Nature, Wu et al.1 describe a powerful method for visualizing...
and elsewhere have been able to pinpoint cells in mouse bone marrow that give rise to specific types of blood cells. They also found evidence of variations in how the skeleton responds to stressors such as infection or blood loss. Details of the findings are published in a newNat...
"BONE MARROW STROMAL CELL MATERIALS FOR USE IN FORMATION OF BLOOD VESSELS AND PRODUCTION OF ANGIOGENIC AND TRAFFIC FACTORS". Therapeutic substance for use in inducing angiogenesis and vasculogenesis, the therapeutic substance including angiogenesis and vasculogenesis inducing factors isolated from stem cells...
Our results strengthen the potential role of MMP-9 in the higher migrational capacity of CB CD34 + cells, which may be beneficial to homing of these cells to the BM environment. 展开 关键词: Cord blood CD34+ progenitors Matrix metalloproteinase-9 Migration Bone marrow ...
- 《Blood》 被引量: 461发表: 2003年 Antisense inhibition of macrophage inflammatory protein 1-α blocks bone destruction in a model of myeloma bone disease We recently identified macrophage inflammatory protein 1-alpha (MIP-1alpha) as a factor produced by multiple myeloma (MM) cells that may ...
In response to anemia, red blood cell production can be expanded several-fold in a rapid but graded manner such that polycythemic overproduction does not occur. Erythropoietin increases survival of erythroid progenitor cells in erythroblastic islands, the marrow niche of terminal erythropoiesis, ...
Radioautography with 3H-thymidine was used to examine the proliferative activity of bone marrow lymphoid cells and to identify the precursor cells of small lymphocytes in short-term cultures of lymphocyte-rich marrow fractions. High conc... Y Yoshida,DG Osmond - 《Blood》 被引量: 64发表: 1971...
Isolation of mouse bone-marrow-derived PMNs PMNs were isolated from C57BL/6 as previously described with modifications [20]. Briefly, the mice were killed and soaked in 70% ethanol. Bone marrow cells were collected by syringe flushing the femurs with phosphate-buffered saline (PBS). PMNs were...
The development of blood cells requires the interplay of hematopoietic stem and progenitor cells, marrow stroma and polypeptide growth factors. Although ma... K Kaushansky - 《Thromb Haemost》 被引量: 314发表: 1995年 Stimulation of megakaryocyte and platelet production by a single dose of recombina...
The in vitro production of mature human red blood cells (RBCs) from induced pluripotent stem cells (iPSCs) has been the focus of research to meet the high demand for blood transfusions. However, limitations like high costs and technological requirements restrict the use of RBCs produced by iPSC...