Production of antibodies in trans- genic plants. Nature 342: 76-77.Hiatt A, Cafferkey R and Bowdish K (1989) Production of antibodies in transgenic plants. Nature 342: 76-78.A. Hiatt, R. Cafferkey, and K. Bowdish, "Production of antibod- ies in transgenic plants," Nature, vol. 342...
Production of antibodies in transgenic plants A functional antibody accumulated to 1.3% of total leaf protein in plants expressing full-length cDNAs containing leader sequences. Specific binding of the ... A Hiatt,R Caffferkey,K Bowdish - 《Nature》 被引量: 1906发表: 1989年 加载更多来源...
production of recombinant SIgA in plantsPlant biotechnology is a new and expanding area of science and it is becoming apparent that plant systems may be valuable for the expression and production of recombinant proteins such as pharmaceuticals, vaccines and in particular, antibodies. A unique...
The role of thiol compounds in increasing Agrobacterium-mediated transformation of soybean cotyledonary-node cells Agrobacterium- mediated transformation of soybean cells and the production of fertile transgenic soybean [ Glycine max (L.) Merrill] plants using the cotyl... P.,Olhoft,K.,... - 《...
Various forms of recombinant monoclonal antibodies are being used increasingly, mainly for therapeutic purposes. This review specifically focuses on what i
Many pharmaceutical proteins have been expressed in plants as part of 'proof of principle' studies, including human and animal proteins, recombinant subunit vaccines and recombinant antibodies. Only a few of these proteins have reached advanced stages of development and even fewer have begun clinical ...
Attaching an scFv antibody fragment to the Aga2p agglutinin effectively mimics the cell surface display of antibodies by B cells in the immune system for affinity maturation in vivo. T cell receptor mutants can be isolated by this ... MC Kieke,KD Wittrup,ET Boder,... - US 被引量: 296发...
Genetic transformation of the regenerated plants growing under selection was demonstrated by PCR,and Southern blot analysis revealed that one to three copies of the transgene were integrated into the plant genome of eachtransgenic plant. Expression of the bar gene in transgenic plants was confirmed by...
Antibodies and their derivatives represent the largest and most important group of biotechnology-derived products currently in clinical trials, and they are expected to attain a market value of 5 billion dollars by 2005 [1]. Production of an IgG antibody in transgenic plants was first described in...
Spleen, lymph nodes and bone marrow are examples of tissues that produce natural antibodies in an animal. The term “introduced” in the context of inserting a nucleic acid sequence into a cell, means “transfection”, or ‘transformation”, or “transduction” and includes reference to the ...