Dysfunction of the enzymes in the Krebs cycle may impact activity of transcription factors such as HIF1伪?? through changes in the amount of the organic acids in the cycle. Study of the mitochondria function also reveals important insights on JmjC-domain proteins, which demethylate histones and ...
(C3H6O3)→ATP↑Fd(red)→ATP↑Nitrogenase→H2 (4) A cultivation of two different organisms in the same bioreactor with proper conditions for both types of bacteria is difficult. This is because they are different in their metabolic types, optimal conditions, and nutritional requirements. The ratio...
Since more NAD(P)H and ATP cofactors are generated in the Krebs cycle-dependent malate production when compared to pathways which depend on the function of anaplerotic PEP carboxylase or PEP carboxykinase enzymes, the engineered strain developed in this study can serve as a platform to increase ...
Nuclei cycle their positions rapidly, within 12-h cell cycles, which implies that they acetylate their histones when they approach the tissue surface and then deacetylate them when moving back deeper into the tissue. Although FABO is increased in the rim region, this is not sufficient to ...
The activity of the citric acid cycle can be monitored by measuring the amount of O2 consumed. The greater the rate of O2 consumption, the faster the rate of the cycle, the faster the rate of ATP production. Hans Krebs in 1937 used this type of experiments, working with fragments of ...
Metabolomic analysis demonstrated that glycine—similarly to low KCN concentrations—stimulates glycolysis and activates the Krebs cycle, while serine/glycine deprivation exerts inhibitory effects (Fig.5cand Extended Data Fig.8). These effects are partially transcriptional: RNA-sequencing (RNA-seq) analysis...
In this study, by using RNA-seq approach, we demonstrated that V-ATPase plays an important role in the regulation of lipid pro- duction, which is associated with energy metabolism, ion transport and cell cycle control. Result and Discussion An increased V-ATPase activity in the culture of P...
Inhibition of Krebs cycle enzymes by hydrogen peroxide: a key role of [alpha]-ketoglutarate dehydrogenase in limiting NADH production under oxidative stress J. Neurosci., 20 (24) (2000), pp. 8972-8979, 10.1523/jneurosci.20-24-08972.2000 View in ScopusGoogle Scholar [149] K.H. Fisher-Wellman...
40 It is assumed that it acts as an accelerator of the Krebs cycle, resulting in the increased formation of cellulose and cell growth.40 The significant effect of succinic acid on BC production enhancement has been reported previously.29, 30 In addition to succinic acid, other organic acids ...
Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle. Nature. 2019;568:571–5. ACKNOWLEDGEMENTS We thank Dr. Xiajuan Zou for assistance in the mass spectrometric analysis, Yun Liu for assistance in the Flow cytometry, and Prof. Bo Zhang for providing us the...