Among the mutants identified in our studies, the added steric bulk in the foot may disfavor an active or processive conformation, reducing the affinity for poor substrates such as RNA templates. A positive correlation between the size of the added amino acid and increased 3′ homogeneity ...
Har- vested biomass of low bulk density is transported to integrated large factories for pretreatment under acid or alkaline conditions to degrade the structural carbohy- drates (Figure 1A). After pretreatment, however, a large * Correspondence: kitamoto@affrc.go.jp † Contributed equally 1...
Pgp (also known as multidrug resistance protein, MDR1 or ABCB1) is a plasma membrane protein with the ability to pump a wide range of hydrophobic substances out of cells using the energy of ATP hydrolysis1,2,3. It is important in determining the pharmacokinetics of drugs by extruding them ...
Previous studies showed that imbalances of trace elements in homeostasis, such as bulk copper [6], bulk iron [7], and zinc [8–10], played an important role in the formation of senile plaques in the brain. Zinc is an essential trace element, required for the functional integrity of many...
The G93A-SOD1 cells showed a significant reduction of the phosphoPKCε/panPKCε ratio compared to the WT. Moreover, a brief pulse activation of PKCε by Bryostatin-1 produced long-term survival in activated G93A-SOD1 degenerating cells in two different cell death paradigms (serum starvation ...