DMC1 is a recombinase that is essential for meiotic synapsis. Experiments in extensive species of eukaryotes have indicated the independent role of DMC1 in repairing double strand breaks (DSBs) produced during meiosis I. Mutation of dmc1 in mice and huma
RAD51, the core DNA repairase, is prone to mediate the repair processes between sister chromatids in mitosis, and was thought as an accessory factor of DMC1 for mediating the repair between homologous chromosomes. During meiosis in yeast, the expression of rad51 decreased to reduce competition ...