Exact mechanism of action is unknown, but may involve binding toGABAA receptors, potentiating the action of endogenousGABA. Originally formulated inCremophor EL, but reformulated before commercial release because of allergic reactions. Now presented as an oil–water emulsion: 1% (presented in...
Mechanism of action The sedative and antiemetic actions of phenothiazines are due to antagonism of dopamine, primarily at D2 receptors. Additional side effects of the phenothiazines can be attributed to their antagonistic activity at other receptors, including α1-adrenergic receptors, H1-histaminergic ...
The mechanism of action in antiemetic use is the inhibition of dopamine signaling in the chemoreceptor trigger zone (CTZ) and the vomiting center. Antipsychotic: Prochlorperazine is also utilized as an antipsychotic medication. Its purpose in this field involves its ability to block dopamine ...
Medical Wikipedia pro·chlor·per·a·zine (prō′klôr-pĕr′ə-zēn′) n. A phenothiazine drug, C20H24ClN3S, used to treat schizophrenia and anxiety and to stop or prevent vomiting. [pro(pyl)+chlor(o)-+(pi)perazine.] American Heritage® Dictionary of the English Language, Fifth...
Prochlorperazine may impair mental and/or physical abilities, especially during the first few days of therapy. Therefore, caution patients about activities requiring alertness (e.g., operating vehicles or machinery). Phenothiazines may intensify or prolong the action of central nervous system depressants...