... gene bank - 基因库 Processed pseudogene - 已加工假基因 gene flow - 基因 …dict.bbioo.com|基于43个网页 2. 加工的假基因 加工的假基因(processed pseudogene) 这类假基因没有与“亲本基因”连锁,而且其 结构是同转录本而非“亲本基因”类似。 加工的 …www.docin.com|基于18个网页...
【答案】：加工型假基因有RNA加工反应的标志，表明某种程度上，它们经历过RNA阶段。例如：某些加工过的假基因没有内含子，另一些则在3'-末端加工过。猜想它们的起源是一个基因被转录为前体mRNA，经加工，然后在反转录酶作用下反转录成DNA，这一反转录的拷贝再整合到基因组上。
A processed pseudogene is similar to mRNA , lacks introns, and may have a polyA tail, yet it is non-functional. The faulty reverse transcription of mRNA may have produced processed pseudogenes. Pseudogenes are widely expressed, generally short, highly conserved, and low in GCs. Many of the ...
Moreover, processed pseudogenes can occur in somatic cells, including in various cancers and in early fetal development. One recent somatic insertion of a processed pseudogene has caused a Mendelian X-linked disease, chronic granulomatous disease....
更多“加工型假基因(processed pseudogene)和其他假基因有什么不同?加工型假基因是如何产生的?”相关的问题 第1题 汽车市场预测按时间长短分类,长期预测是指()年以上。 A.1 B. 5 C. 10 D. 15 点击查看答案 第2题 主要的决策分类方法有 A.按成本类型分类 B.按风险分类 C.按时间长短分类 D.按决策...
Using whole-genome sequencing (WGS), we identified an integration of the processed pseudogene NPM1 deep in the intron 5 of GLB1. The patient’s mRNA analysis and the detailed functional analysis revealed the underlying molecular genetic mechanism of pathogenesis, which is an alteration of the GLB...
This study also indicates how a processed pseudogene may confound quantitative results, dependent on placement of probes and/or primers in a particular assay design, potentially leading to both false-positive and false-negative results. We also found that the SMAD4 processed pseudogene affects next-...
Because of the lack of intron 1 sequence and the likely lack of expression, the new sequence is most probably a part of a VHL processed pseudogene. The putative pseudogene was mapped to human chromosome band 1q12 using the polymerase chain reaction with template DNA from human/rodent somatic ...
The presence of processed pseudogenes seems peculiar to mammals. In fact, evolutionary studies indicate that processed pseudogenes are of relatively recent origin. In fact, at least one processed pseudogene, the human DHFR psi 1, has been formed so recently that it is polymorphic. 展开 ...
Two different hypotheses have been proposed to explain the observation that some genomes contain more processed pseudogenes than others. One predicts that processed pseudogene abundance is inversely proportional to the substrate specificity of the reverse transcriptase that generates processed pseudogenes. The...