Procainamide is a class la anti-arrhythmic used in a wide range of cardiac arrhythmias with properties similar to quinidine. The short duration of action and high incidence of side-effects generally limit its use to the acute control of arrhythmias where the less marked hypotensive action on ...
Side effects:Adverse effects include rash, myalgia, hypersensitivity reactions (fever, agranulocytosis), Drug-Induced Lupus Erythematosus (particularly in slow-acetylators), and proarrhythmic effects (e.g., torsades de pointes). Treatment with procainamide can cause antibody production against cellular...
Precautions Patient Counseling Information Drug Interactions Adverse Reactions/Side Effects Overdosage Dosage and Administration How Supplied/Storage and HandlingWARNING: The prolonged administration of procainamide often leads to the development of a positive anti-nuclear antibody (ANA) test, with or without...
Itwas developed in the course of research for compoundsstructurally similar to procaine, which had limited effectas an antiarrhythmic agent because of its central nervoussystem (CNS) side effects and short-lived action causedby rapid hydrolysis of its ester linkage by plasma esterases.Because of its...
Problematic side effects of Procainamide include myalgia, rash and hypersensitivity reactions (such as agranulocytosis and fever). In some cases, Procainamide may cause autoimmue antibody production against cellular components, which can lead to systemic lupus erythematosus-like reactions.Funck-Brentano...
Problematic side effects of Procainamide include myalgia, rash and hypersensitivity reactions (such as agranulocytosis and fever). In some cases, Procainamide may cause autoimmue antibody production against cellular components, which can lead to systemic lupus erythematosus-like reactions.Funck-Brentano...
During single-drug treatment, the maximum tolerated dose of quinidine without extracardiac dose-related side effects was 1.6 ± 0.21 g/day and that of procainamide was 4.1 ± 1.05 g/day. During combination therapy with smaller doses (p < 0.05) of quinidine (1.16 ± 0.26 g/day) and ...
The serum concentration of procainamide was 2–4 times higher than the recommended upper level, but no side‐effects were observed. With the dose given, one would have expected still higher serum concentrations. Several reasons for this finding are discussed, including the effects of renal function...
NAPA therapy was associated with positive antinuclear antibody titers in only one patient and seems less prone to cause drug-induced lupus erythematosus than procainamide, but NAPA shares the gastrointestinal and other side effects of procainamide. Clinical Pharmacology and Therapeutics (1983) 33, 565鈥...
The mean plasma concentration of acecainide associated with efficacy was 14.3 /gm/ml (range 9.4 to 19.5) and with side effects (primarlly gastrointestinal) was 22.5 渭g/ml (10.6 to 37.9). The antiarrhythmic response to procainamide did not predict response to acecainide; this finding implies...