Omeprazole has been marketed successfully after a prolonged development phase characterized by difficult problems with the toxicity studies. Against the background of these two descriptions, this article questions the rationale for the present rules for long-term toxicity studies and emphasizes the need ...
When you look at a global marketplace and supply chain in which more than 70 different serialization standards and regulations exist, it is easy to see how a patchwork solution architecture would not be viable in the long term. Accessing Data, Unlocking Information Much of pharma's data today...
Behavioral monitoring and urine toxicology testing in patients receiving long-term opioid therapy Anesth Analg, 97 (2003), pp. 1097-1102 View in ScopusGoogle Scholar 55 M.J. Krantz Heterogeneous impact of methadone on the QTc interval: What are the practical implications? J Addict Dis, 27 (200...
with budesonide as the treatment of choice, first generation antihistamines, or cetirizine (third trimester) and loratadine (second and third trimester) from the second generation, H2 receptor antagonists (except nizatidine) and proton pump inhibitors (except omeprazole), can be used to relieve patient...
Food and Drug Administration (FDA) has determined that omeprazole and esomeprazole are not likely to be associated with an increased risk of heart problems after long-term use. Because of the findings of the scientific studies of the FDA, healthcare providers are advised to continue to prescribe...
Profound suppression of gastric acid is associated with increased severity of H pylori gastritis. This prospective randomised study aimed to investigate whether H pylori eradication can influence gastritis and its sequelae during long term omeprazole therapy for gastro-oesophageal reflux disease (GORD). ...
omeprazoleBackground-Eradication of Barrett's mucosa by thermal or photoablation combined with high doses of proton pump inhibitors is a potentially attractive strategy in the management of this preneoplastic condition. However, major concerns of this method are the persistence of residual metaplastic ...
Long-term use of the proton pump inhibitors (PPIs) omeprazole (Prilosec) and esomeprazole (Nexium), both manufactured by AstraZeneca, probably will not increase the risk of cardiac events, the FDA has concluded following a comprehensive and scientific review of safety data for the drugs.This ...
Interaction of tamoxifen with the multidrug resistance P-glycoprotein. Br. J. Cancer 1995, 71, 294–299. [Google Scholar] [CrossRef] [PubMed] [Green Version] Pauli-Magnus, C.; Rekersbrink, S.; Klotz, U.; Fromm, M.F. Interaction of omeprazole, lansoprazole and pantoprazole with P-...