upregulation [62]. NO promotes smooth muscle cell vasodilation through cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) [63]. NO also inhibits vasoconstriction by impeding 20-hydroxyeicosatetraenoic acid (20-HETE) synthesis [59]. Inhibiting nNOS has been shown to reduce neurovascul...
Ito, H. Iwasaki et al., “Rho/Rho-kinase pathway contributes to C-reactive protein-induced plasminogen activator inhibitor-1 expression in endothelial cells,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 25, no. 10, pp. 2088–2093, 2005. [174] L. Jin, Z. Ying, and R. C....
On the other hand, the non-statistically significant trend of prazosin to decrease ROS might be related to that the antagonism of α1-adrenergic receptors inhibits the diacylglycerol-protein kinase C (DAG-PKC) pathway. This pathway is involved in ROS production by activating Nox in endothelial cel...