pre-pro-B cells, pro-B cells, pre-B cells, immature B cells, and then more mature and specialized B cells. By the time the development hits the pro-B stage, the cell is fated to stay a B cell rather than another type of cell. ...
IL-7 sensitizes human pre-B cells but not pro-B cells to Fas/APO-1 (CD95)-mediated apoptosis. Clin. Exp. Immunol. 110:329-335.Levy Y, Benlagha K, Buzyn A, Colombel M, Brouet JC, Lassoued K. IL-7 sensitizes human pre-B cells but not pro-B cells to Fas/APO-1 (CD95)-...
To investigate the function of SHPS-1 in a hematopoietic cell line, SHPS-1 was expressed in Ba/F3 cells, an IL-3-dependent pro-B-cell line that lacks endogenous SHPS-1 protein. Interestingly, expression of either SHPS-1, or a mutant lacking the intracellular domain of SHPS-1 (Delta...
Surprisingly, we discovered that in normal human pro-B cells, the predominant transcript used an alternative first exon to produce the poorly characterized FBXW7β isoform, previously thought to be restricted to neural tissues. The FBXW7β transcript was also abundant in cell lines and primary ...
Noncoding transcription within the Igh distal V(H) region at PAIR elements affects the 3D structure of the Igh locus in pro-B cells Noncoding sense and antisense germ-line transcription within the Ig heavy chain locus precedes V(D)J recombination and has been proposed to be associated w......
B cells. Notably, the Wapl protein was expressed at a 2.2-fold higher level in pre-B cells compared with pro-B cells, which resulted in a distinct chromosomal architecture with normal loop sizes in pre-B cells. High-resolution chromosomal contact analysis of theIgklocus identified multiple ...
Cutting edge: CD19 + pro-B cells can give rise to dendritic cells in vitro. J Immunol. 1998;161:5795–5799.Bjorck P,Kincade PW.Cutting edge:CD19... P Bjorck,PW Kincade - 《Journal of Immunology》 被引量: 0发表: 1998年 In vitro identification of human pro-B cells that give rise ...
structure of the Igh locus in pro-B cells. If this hypothesis were true, a prerequisite would be that there would be many CTCF binding sites throughout the V H locus. Indeed, we previously reported >50 sites of CTCF binding throughout the V H locus in the pro–B-cell stage using chro...
marrow pro-B cells. SMARD analysis of DNA replication in mouse bone marrow pro-B cells.SMARD analysis of DNA replication in mouse bone marrow pro-B cells.Michel, G. GauthierPaolo, NorioJohn, Bechhoefer
During B-cell development, cells progress through multiple developmental stages, with the pro-B-cell stage defining commitmentto the B-cell lineage. YY1 is a ubiquitous transcription factor that is capable of both activation and repression functions.We found here that knockout of YY1 at the pro-...