Cellular biology Hepatic stellate cell transdifferentiation| Pro-fibrogenic effectors THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE Laura W. Schrum LaknerAshley MarieHepatic fibrosis is a significant cause of morbidity and mortality worldwide and can be described as exacerbated wound-healing marked by ...
Exogenous HMGB1 can induce the proliferation of human dermal fibroblasts, and could act as a profibrogenic molecule to produce collagen, decrease MMP-1, and increase TIMP-1 mRNA expression. Moreover, administration of HMGB1 increased the expression level of TGF-β1 and internal signaling molecules,...
Joseph GeorgeMikihiro TsutsumiMutsumi TsuchishimaWileyJournal of Cellular and Molecular MedicineGeorge, J.; Tsutsumi, M.; Tsuchishima, M. MMP-13 deletion decreases profibrogenic molecules and attenuates N-nitrosodimethylamine-induced liver injury and fibrosis in mice. J. Cell Mol. Med. 2017, 21, ...
网络细胞激素 网络释义 1. 细胞激素 纤维化的细胞激素(Profibrogenic cytokines) 关於疾病的表现与基因的多样性 之间的关系,这领域的研究目前正快速的进展。几… www.docin.com|基于 1 个网页
Gremlin is a Key Pro-fibrogenic Factor in Chronic Pancreatitis Sample Page Abbott EIA AxSYM (Abbott, Abbott Park, IL, USA) was employed for HBsAg, HBeAg, and anti-HBe March 4, 2025/Salvador Moreno Abbott EIA AxSYM (Abbott, Abbott Park, IL, USA) was employed for HBsAg, HBeAg, an...
Pro-proliferative effects of bile salts on HSCs (i.e., increase in BrdU incorporation) have only been demonstrated in two previous studies, and subsequent pro-fibrogenic down-stream effects (e.g., cell mass, collagen deposition) have never been investigated. Both hydrophilic and hydrophobic bile...
Renal tubular epithelial cells (TECs) play a key role in renal fibrogenesis. After persistent injuries that are beyond self-healing capacity, TECs will dedifferentiate, undergo growth arrest, convert to profibrogenic phenotypes, and resort to maladaptive
In chronic liver disease, approaches opposing profibrogenic activities of TGF-β may be amenable. According to experimental models IFN-γ counteracts several TGF-β effects. Here, the impact of IFN-γ on hepatic fibrosis in patients with chronic hepatitis B viral (HBV) infection with emphasis on...
573 Adipocyte and Preadipocyte Derived-Mediators Induce a PRO-Fibrogenic Phenotype in Human Intestinal Mesenchymal Cells -A Novel Link Between Fat and Intestinal Fibrosis573 Adipocyte and Preadipocyte Derived-Mediators Induce a PRO-Fibrogenic Phenotype in Human Intestinal Mesenchymal Cells -A Novel Link Bet...
Depletion of GIV, or targeted inhibition of its GEF function, reverses the profibrogenic programme in HSCs, that is, suppresses Akt activity and increases cellular cAMP, thereby 'resetting' the balance to an antifibrogenic programme, as exists in the normal liver. We conclude that GIV is a ...