Specialized pro-resolving mediatorsPurpose of the review:Fish oil (FO) supplementation has historically been used by individuals suffering from cardiovascular disease and other inflammatory processes. However, a meta-analysis of several large randomized control trials (RCTs) suggested FO conferred no ...
Acute inflammation is a self-limiting process of the immune system, which resolves through the initiation of a program referred to as the resolution of inflammation. It has been argued that uncontrolled inflammation may be the basis of a variety of chron
More recently, a major advancement in the field of PUFA and inflammation has been the discovery of the so-called pro-resolving lipid mediators produced from EPA and DHA. These mediators include resolvins from EPA (E-series) and DHA (D-series) and protectin and maresin from DHA. Their synthe...
[3]. Lipoxins and Rvs appear to be important mediators of the surgical stress response. In rodents, surgery-induced release of IL-6 was inhibited by aspirin-triggered RvD1 [4]. In an experimental model of peritonitis, the administration of fish oil (a natural source of eicosapentaenoic and ...
Specialized pro-resolving mediators: endogenous regulators of infection and inflammation. Nat Rev Immunol. 2016;16:51–67. Article CAS PubMed Google Scholar Terrando N, Gomez-Galan M, Yang T, Carlstrom M, Gustavsson D, Harding RE, Lindskog M, Eriksson LI. Aspirin-triggered resolvin D1 ...
Plasma levels of specialized pro-resolving lipid mediators (SPMs) were measured by liquid-chromatography-tandem mass spectrometry. In patients treated with fish oil, the absolute mean omega-3 index significantly increased from baseline (fish oil: 7.2卤1.2%, P<0.001; placebo: -0.4卤0.9%, P=0.31...
Background Omega-3 fatty acid-derived 'specialized pro-resolving mediators' (SPM) are low-abundance lipid mediators (LM) central to inflammation resolution. We investigated whether fish oil (FO) supplementation was associated with pro-inflammatory and pro-resolving LM in patients with SLE compared ...
Fish oilsSpecialized pro-resolving lipid mediatorsOther pharmacotherapyBackground: N-3 polyunsaturated fatty acid (PUFA) supplementation has been associated with reduced mortality and inflammation in patients with cardiovascular disease. There are limited data on the effects of n-3 PUFA supplementation in ...
The present invention relates to a specialized pro-resolving lipid mediator comprising maresins, D-series resolvins, E-series resolvins, protectins or lipoxins, or a combination the
Dietary fish oil decreases the production of pro-inflammatory mediators by murine macrophages: Fiona Wallace, Sarah Neely, Elizabeth Miles and Philip Calder, School of Biological Sciences, University of Southampton, Southampton, U.K. - ScienceDirect...