Resolvins and maresins are the two principal kinds of specialized pro-resolving mediators (PRMs, also known as SPMs). They’re created by the body from fatty acids such as EPA and DHA omega-3s.1 More These stat
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Although various forms of ROS, including superoxide, hydroxyl radical, and reactive nitrogen species, such as peroxynitrite, have been implicated as mediators of oxidative damage, the less reactive H2O2 has emerged as a key mediator of redox signaling (9, 10). H2O2 regulates specific signaling even...
(Oct4, Sox2, Klf4, c-Myc) that could overcome the inhibitory effects of RNaseH1 activity loss on reprogramming; (iii) DDX5 was a reprogramming barrier factor and Sox2 interacted with and inhibited DDX5 helicase activity-mediated R-loop–resolving capacity on R-loop sites and thus facilitated...
As well as the endogenous lipoxin molecules, LXA4 (1) and LXB4 (2), other specialised pro-resolving mediators, such as resolvins, protectins and maresins, also play an important role in the resolution of inflammation (Figure 1) [8]. Figure 1. Native LXA4 (1) and LXB4 (2). ...