Previous reports have demonstrated that PPARγ is cleaved by caspase-1, 3 and 617,18. We have found that PPARγ cleavage in cocultured TAMs is blocked by the pan-caspase inhibitor NCX-401619(Supplementary Fig.2c). Unexpectedly, we detected an increase in the activity of caspase-1, but no...
13 reagents referenced in Human procaspase-1 variants with decreased enzymatic activity are associated with febrile episodes and may contribute to inflammation via RIP2 and NF-κB signaling.
当NOD样受体组装成大型复合物时,caspase-1作为内源性蛋白酶,切割Pro-IL-1β生成具有活性的成熟IL-1β (mature IL-1β)。先前的研究表明,IL-1β是A组链球菌 (GAS) 蛋白酶SpeB的先天性免疫感受器 (LaRock CN, Sci Immunol, 2016)。然而,IL-1β是否是病毒蛋白酶的炎症感受器尚未报道。 研究人员首次报道塞内...
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(cleaved caspase-1 and cleaved gasdermin D) in liver parenchyma treated with IRE19. Furthermore, in vitro studies indicate that it takes 1.5–2.5 h from the onset of necroptotic injury to when cells demonstrate SYTOX+nuclei37, consistent with the timing of SYTOX+nuclei appearance in vivo ...
The procaspase-activating compounds (PAC-1), including B-PAC-1 (L14R8), convert inactive executioner procaspases to their active cleaved forms by chelation of labile zinc ions. Both at transcript and protein levels, primary CLL cells express high levels of latent procaspases (3, -7, and -...
Citicoline reduced the expression of all procaspases at 12 and 24 h after MCAO, as well as the expression of cleaved caspase-3 in cells in the penumbra area. This was accompanied by a reduction in the number of cells bearing nuclear DNA fragments. The expression of caspase-cleaved products ...
in cleaved caspase-3 protein were observed in human ovarian granulosa cells transfected with pre-mir-23a, along with an increased occurrence of apoptosis. ... X.,Yang,Y.,... - 《Reproduction》 被引量: 189发表: 2012年 Caspase-3, TUNEL and ultrastructural studies of small follicles in adult...
(Santa Cruz Biotechnology, Santa Cruz, CA, USA); and Hsp70, c-Raf, Akt, ERK1/2, phosphorylated-ERK1/2 Thr202/Tyr204(p-ERK1/2), cyclin D1, phosphorylated RbSer780 (p-Rb), Bim, BAK, cleaved caspase-9, cleaved caspase-3, β-actin, and horseradish peroxidase-linked anti-mouse and...
recruits and matures pro-caspase-1 to form inflammasomes, which then releases N-terminal fragments from gasdermin D (GSDMD) to form pores in the cell membrane. Interleukin (IL)-1β and IL-18 are also cleaved by caspase-1 and leaks through the cellular pores. Considering the roles of the ...