2014. Post-transcrip- tional modification of pro-BNP in heart failure: is glycosyl- ation and circulating furin key for cardiovascular homeo- stasis? Eur Heart J 35:3001-3003.Ichiki T, Burnett JC Jr. Post-transcriptional modification of pro-BNP in heart failure: is glycosylation and ...
慢性心力衰竭(chronic heart failure,CHF)属于大部分心血管疾病进展最终结果,CHF患者预后较差,心血管事件不良发生率、再住院率以及死亡率均较高[1-2]。因此,早期客观评估CHF预后显得尤为重要。心室壁受到牵张时Pro-BNP被释放,其在蛋白酶作用下列解为氨基末端BNP前体(NT-proBNP)和BNP。有研究认为,NT-proBNP代谢速度较...
在无急性发作的患者中，BNP和NT-proBNP诊断心衰的敏感性和特异性相对较低 NP阈值随年龄增大而增加，但随体重指数增加而减少 AmHeartJ.2006May;151(5):999-1005.Howobesityaffectsthecut-pointsforB-typenatriureticpeptideinthediagnosisofacutecongestiveheartfailure AmHeartJ.2006May;151(5):999-1005 Thegreyzone B...
[Keywords]pro-BNPlevel;PCTlevel;Chronicobstructivepulmonarydisease acuteexacerbations;Heartfailure 慢阻肺(COPD)可能與呼吸系统进入有害气体及颗粒诱发呼吸道产生炎症 异常反应相关,是由慢性肺气肿与(或)支气管炎不断加重导致气流受阻的慢性 疾病[1]。致使AECOPD发生的病因与感染有关,特别是细菌感染[2],与心力衰 ...
The present study sought to evaluate the clinical utility of pro-B-type natriuretic peptides (proBNP) in patients admitted with acute decompensated heart failure. Background Plasma natriuretic peptides (BNP1–32, N-terminal [NT]-proBNP1–76) have been demonstrated to assist in the diagnosis of...
Heart failure (HF) is a progressive disease. Natriuretic peptides such as unprocessed pro-BNP1–108 may inform risk stratification. We studied 187 Class III–IV patients by serial blood sampling every 3months for 2years. Circulating levels of pro-BNP1–108 are comparable to mature BNP in ambu...
Conclusion Plasma pro-BNP can objectively reflect the cardiac function,and it is an important basis for clinical diagnosis of heart failure.PCT can accurately reflect the severity of AECOPD.The combination of the two methods is of positive significance for the assessment of heart failure in patients...
而目前关于血浆NTpro-BNP和BNP水平联合诊治急性失代偿性心衰等心脏疾病的研究报道甚少。明确急性失代偿性心衰患者NTpro-BNP/BNP预测其预后的价值可为其预后的早期评估干预从而改善预后情况提供有力的临床依据。本研究结果显示,急性失代偿性心衰患者血浆NTpro-BNP和BNP水平及NTpro-BNP/BNP均明显较高,而随着治疗时间的...
levelsofsST2,pro—BNP,high—sensitivetroponinandE/Aintheexperimentgroup.4.Therewasalinearcorrelation betweenlevelsofsST2,pro—BNPandhigh—sensitivetroponin.ConclusionsST2,pro—BNPandhigh-sensitivetroponin participateinthepathologicalandphysiologicalprocessesofheartfailure,whichareimportanttodiagnosetheearliernormal ...
目的:分析血清Gal-3,NT-pro-BNP在慢性心力衰竭(CHF)中的表达及临床意义.方法:选取108例慢性心力衰竭患者作为观察对象,采用电化学发光法检测血清半乳糖凝集素-3(Gal-3)和氨基末端脑钠肽前体(NT-pro-BNP)水平,采用超声心动图检测左室射血分数(LVEF),比较不同心功能分级和是否发生不良心血管事件(MACE)患者的血清...