Pro-survival and pro-apoptotic factors following axotomy in a murine model of Amyotrophic Lateral SclerosisThe facial nerve axotomy is used to study motoneuron (MN) survival and peripheral nerve regeneration. Using this model in wild-type (WT) mice we have identified two populations of MN; ...
Dominko Carev,Dragan Krni,Marijan Saraga,Damir Sapunar,Mirna Saraga-Babi. Role of mitotic, pro-apoptotic and anti-apoptotic factors in human kidney development[J]. Pediatric Nephrology . 2006 (5)Dominko C,Dragan K,Marijan S,Damir S,Mirna SB.Role of mitotic, pro-apoptotic and anti-...
-expression factors Proapoptotic role of novel gene-expression factorsProapoptotic role of novel gene-expression factorsApoptosisGene expressionSplicing factorsCancerThe mechanisms that control cellular proliferation, as well as those related with programmed cell death or apopotosis, require precise regulation...
IFN-γ−/−and Prf1−/−CAR4 T cells, respectively. Two-way ANOVA and Sidak’s multiple comparisons were used for statistical analysis.d, A direct killing index was calculated as the ratio of normalized direct apoptotic events to the surface occupied by CAR T cells in each image. Eac...
et al. Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors. Nat Chem Biol 1, 223–232 (2005). Article CAS PubMed Google Scholar Huttemann, M. et al. The multiple functions of cytochrome c and their regulation in life and death decisions of the ...
Concurrently, there is a dose-dependent increase in levels of anti-apoptotic Bcl2. Previous studies have shown that both apoptotic and anti-apoptotic factors are up-regulated in human tumours, and this leads to an impairment of the apoptotic signaling pathway and can confer resistance to apoptosis...
Cell-penetrating TAT-FOXO3 fusion proteins induce apoptotic cell death in leukemic cells. FOXO proteins are Akt-regulated transcription factors involved in the control of cell cycle, DNA repair, stress defense, apoptosis, and tumor suppression. ... Makram,Essafi,D Alice,... - 《Molecular Cancer...
Mitochondrial potential loss might be resulted from increased permeability of mitochondria membrane, which led to the release of apoptotic factors to activate the intrinsic apoptosis pathway. Meanwhile, damage of mitochondria can also result in accumulation of reactive oxygen species (ROS), and the ...
similar HSF1 binding did not result in similar changes in expression when both types of cells were compared. Even in spermatocytes subjected to hyperthermia at 38°C and 43°C, HSF1-bound genes were differentially regulated after heat shock. This finding suggests that factors responsible for HSF...
(ECM) and cells, and it controls cell proliferation and anti-apoptosis. The transcriptional coactivator YAP1 is an effector of this pathway; it translocates into the nucleus when activated, where it regulates the expression of stem cell factors, such asSOX2andOCT4, and anti-apoptotic factors, ...