Full size image Table 1 Allele frequencies of PRNP polymorphisms at codons 127, 142, 146, 154, 211, 222 and 240 in the studied populations Full size table There were few amino acid substitutions in the three populations (2.1–12.7%), with an average substitution of 11.4%. The only excepti...
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Results 147 of 166 confirmed cases of variant CJD (vCJD) in the UK have had PRNP codon 129 genotyping and all are methionine homozygous at codon 129; 118 have had full PRNP gene sequencing. Of the latter, 5 cases have shown other polymorphic loci: at codon 219 (2, 1.69%), at codon...
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