PRMT inhibitorsmall moleculespinal muscular atrophySpinal muscular atrophy (SMA) is a leading genetic cause of infant mortality. The advent of approved treatments for this devastating condition has significantly changed SMA patients' life expectancy and quality of life. Nevertheless...
Full size image As noted above, PRMT2 is a known inhibitor of NF-kappa B with a mechanism involving blocking nuclear export of I kappa B-alpha, resulting in decreased NF-kappa B binding to its transcriptional targets12. Thus, we hypothesize that the increases in the expression of targets o...
The cells were then resuspended in lysis buffer (50 mm Tris-HCl, pH 7.5, 150 mm NaCl, 0.1% Triton X-100, 10% glycerol, 2 mm MgCl2, 1 mm DTT, Complete protease inhibitor mixture (Roche), and 40 units/ml RNase OUT (Life Technologies)) and incubated 15 min at 4 °C. Lysate was ...
Chelation-assisted de-aryloxylative amination of 2-aryloxy quinolines: a new synthetic route to a key fragment of a bioactive PRMT5 inhibitorA highly regioselective de-aryloxylative amination of O- or N-chelating group-functionalized 2-... A Gupta,J Kumar,S Bhadra - 《Organic & Biomolecular ...