1. PRKCQ〢S1 could promote CRC cell proliferation and migration via miR87/YBX1 axis. 2. PRKCQ〢S1 could promote tumor progression in vivo. 3. The study reveals PRKCQ〢S1/miR87/YBX1 axis for the first time. 4. PRKCQ〢S1 could be regarded as a therapeutic target in CRC treatment.doi:...
PRKCQ-AS1敲低后的DEGs并进行KEGG通路富集;Western blot检测p-Akt和Akt的水平.结果 RNA-seq结果显示,PRKCQ-AS1是上调最明显的DEGs之一.PRKCQ-AS1过表达促进了ASMCs的增殖和迁移并抑制了其凋亡,同时,PRKCQ-AS1过表达使上清液中炎性因子TNF-α和IL-1β的水平升高,而PRKCQ-AS1敲低则呈现相反的结果.对PRKCQ-AS1敲...
Analysis of Immune and Prognostic-Related lncRNA PRKCQ-AS1 for Predicting Prognosis and Regulating Effect in Sepsis Xian Ding, Wenqi Liang, Hongjuan Xia, Yuee Liu, Shuxiong Liu, Xinyu Xia, show all Pages 279-299 | Received 28 Aug 2023, Accepted 07 Dec 2023, Published online: 11 ...
Then we verified the expression of PRKCQ-AS1 in MDS patients and features in SKM-1 cells.Results: Bioinformatics analysis revealed that the DNMT-associated DE-lncRNA PRKCQ-AS1 was functionally related to DNA methylation. The target genes of PRKCQ-AS1 associated with DNA methylation ...
miR-143-3pIL-6/STAT3通路肝癌增殖凋亡目的:探讨lncRNA PRKCQ-AS1对肝癌细胞增殖,迁移,侵袭及诱导凋亡的影响及分子机制.方法:Hep3B细胞分为si-NC组,si-PRKCQ-AS1组,pcDNA-NC组,pcDNA-PRKCQ-AS1组,miR-NC组,miR-143-3p组,anti-miR-NC组,anti-miR-143-3p组,si-PRKCQ-AS1+anti-miR-NC组,si-PRKCQ-AS1+...
Cell function tests confirmed that PRKCQ-AS1 could inhibit sepsis model cells viability and promote cell apoptosis, inflammatory damage and oxidative stress.Conclusion We constructed immune-related lncRNA-mRNA regulatory networks in the progression of sepsis and confirmed that PRKCQ-AS1 is an important ...