Pan-cancerTherapeutic targetsTumor microenvironmentAlthough cancer-associated fibroblasts (CAFs) are viewed as a promising therapeutic target, the design of rational therapy has been hampered by two key obstacles. First, attempts to ablate CAFs have resulted in significant toxicity because currently used ...
Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens. Nature. 2019;568:511–6. 7. Meyers RM, Bryan JG, McFarland JM, Weir BA, Sizemore AE, Xu H, et al. Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells...
Understanding the complete landscape of mutations that drive cancer remains an open challenge for precision oncology and it could help in revealing novel tumor-specific therapeutic vulnerabilities [5]. Many research efforts have been spent on accurately characterizing all these molecular alterations. The ...
Oncological and therapeutic expertise We have a particular focus in oncology and specialty therapeutics, with more than 100 oncology specialists on our team—many with a commercial pharmaceutical background—and more than 25 years of experience. Specialized pharmaceutical consulting Our consultants help ...
a deep learning algorithm with high accuracy in retention time prediction. Analysis of three cancer data sets with a total of 287 tumor samples using different quality control strategies results in substantially different numbers of identified variant peptides and putative neoantigens. Our systematic eva...
6, 2025 /PRNewswire/ -- I-Mab (NASDAQ: IMAB) (the "Company"), a U.S.-based, global biotech company, focused on the development of precision immuno-oncology agents for the treatment of cancer, today highlighted its strategic outlook f...
In this current research work, we evaluated thousands of asthma associated molecular targets and patient expression datasets to identify most relevant therapeutic targets for clinical development. We leveraged the proprietary Ontosight®Discover platform (https://ontosight.ai/) (US20200090789A1) which ...
Consensus strategy was proved to be highly efficient in the recognition of gene-disease association. Therefore, the main objective of this study was to apply theoretical approaches to explore genes and communities directly involved in breast cancer (BC)
These 24 uncertainties were prioritized in a final workshop where a balanced number of patients, carers and HCPs selected the top 10 therapy uncertainties. The final list includes interventions in wound care, itch and pain management, treatment and prevention of syndactyly, cancer prevention and ...
Our analysis extends the spectrum of cancer-relevant genes and identifies novel potential therapeutic targets. Background Rapid developments in sequencing technologies allowed comprehensive cataloguing of somatic mutations in cancer. Early mutation-frequency-based methods identified highly recurrent mutations in ...