Hughes JP, Rees S, Kalindjian SB, Principles of early drug discovery. Brit J Pharmacol 2011 ;162(6):1239-49 •• A concise introduction to the topic of drug discovery.J.P. Hughes et al., Principles of early drug discovery. Br. J. Pharmacol. 162 , 1239–1249 (2011)...
It may take many years to build up a body of supporting evidence before selecting a target for a costly drug discovery programme. Once a target has been chosen, the pharmaceutical industry and more recently some academic centres have streamlined a number of early processes to identify molecules ...
In the early stages of drug discovery campaigns, most hits are commonly in the low millimolar to high micromolar range. As hits get further optimized and become leads, their affinity for the target of interest usually reaches the nanomolar range, and, in so...
Basic Principles of Drug Discovery and Development Benjamin E. Blass 2015 Book Small Molecule Drug Discovery Editors-in-Chief: Andrea Trabocchi and Elena Lenci 2020 Book Chemical Sciences in Early Drug Discovery Pierfausto Seneci 2018 Book Drug-Like Properties Li Di and Edward H. Kerns Second Edit...
This book bridges the knowledge gaps that invariably lead to communication issues in a new scientist’s early career, providing a fundamental understanding of the various techniques and disciplines required for the multifaceted endeavor of drug research and development. It provides students, new ...
Developed a sequence-based system to track 500,000 yeast lineages, thus simultaneously revealing significant differences in early and later evolutionary events. CAS PubMed PubMed Central Google Scholar Qi, H. et al. A quantitative high-resolution genetic profile rapidly identifies sequence determinants...
Very early in life, the deviations from the critical point are small, and the evolution of the organism state is dominated by diffusion. Later in life, the linear term takes over such that the deviations from the youthful state accelerate exponentially: ...
(p3),(p4) The concept of protein ubiquitination, proposed as early as 1980 by Rose, Herschko and Ciechanover, earned them the Nobel Prize in 2004. Their work revolutionized our understanding of protein degradation and regulatory processes within cells, paving the way for advancements in treating ...
Early diagnosis and treatment of RA are crucial, while pharmaceutical therapy currently dominates clinical practice [3]. Although RA management has revolutionized over time, resulting in higher disease remission levels and better long-term outcomes. Great challenges still remain, and the focus now is ...
et al. Proteogenomic characterization of human early-onset gastric cancer. Cancer Cell 35, 111–124.e10 (2019). CAS PubMed Google Scholar Vasaikar, S. et al. Proteogenomic analysis of human colon cancer reveals new therapeutic opportunities. Cell 177, 1035–1049.e19 (2019). CAS PubMed ...