Arguably the most famous principle of toxicology is "The dose makes the poison" formulated by Paracelsus in the 16th century. Application of the Paracelsus's principle to mechanistic toxicology may be challenging as one compound may affect many molecular pathways at different dos...
we have witnessed great strides in understanding the development and evolution of the cerebral cortex, arguably the structure that makes us human” [1]. The cerebral cortex is the biological substrate of our unique cognitive abilities, including memory, complex reasoning, and ...
Specificity reflects the differential reactivity inherent in chemical structure and in the biological niches in which chemicals interact. Just as Paracelsus is identified with the first law of toxicology, the dose makes the poison, Par, a century French surgeon, should be credited with an early ...