On top of errors in signaling or possible meiotic damage during primordial follicle formation, the pool of oocyte quantity plummets to 20% of the original pool. Apoptosis is thought to be the prime mechanism of oocyte death during this transition [20]. The BCL2 family of apoptotic regulators,...
The insulin receptor substrate 1 (IRS1), phosphoinositide 3-kinase (Pi3k), protein kinase B (Akt1), Forkhead Box O3a (FOXO3a) pathway is directly involved in aging and ovarian activation of follicle growth. Therefore, the aim of this work was to measure
TAF4b-deficient ovaries contain normal germ cell densities late in embryogenesis.TAF4b-deficient mouse ovaries suffer accelerated oocyte depletion at birth.TAF4b is required or the proper timing of normal cyst breakdown in the mouse ovary.Excessive germ cell loss in TAF4bs absence is coincident with...
Further, the results presented here demonstrate that oocyte CK1α deletion impairs follicle development and causes infertility. Firstly, this may result from the defects in the cyst breakdown and formation of primordial follicles caused by the dysregulated meiosis in the cKO mice as presented in this ...
OocytesurvivalPrimordialfolliclePrimaryovarianinsufficiencyPrimary ovarian insufficiency (POI) affects 1% of women under the age of 40 and is associated with premature ovarian follicle depletion. \\\{TAF4b\\\} deficiency in adult female mouse models results in hallmarks of \\\{POI\\\} including...
The primordial follicle growth signals the transition of the primordial follicle from quiescence to the next growth state—the primary follicle stage. As the process commences, the oocytes begin to grow and the granulosa cells around the oocyte become cubiform and proliferate rapidly. When the cubi...
Knockdown ofin neonatal ovaries resulted in significant PF loss owing to oocyte apoptosis. In addition, the expression pattern of NOBOX is similar to that of E-cad. Knockdown ofresulted in a decreased NOBOX level, whereas overexpression ofpartially rescued the follicle loss induced by silencing. ...
Moreover, when mothers are exposed to DEHP during pregnancy, their F1 female offspring have a decreased ovarian reserve, the reduced oocyte quality, and an accelerated follicle recruitment. Similar ovarian phenotypic changes may also be detected in F2 and F3 offspring, which indicates that DEHP has...
Our results show that the mammalian oocyte serves as the headquarters of programming of follicle activation and that the oocyte PTEN-PI3K pathway governs follicle activation through control of initiation of oocyte growth. 展开 关键词: Ovary Ovarian Follicle Oocytes Animals Mice, Transgenic Mice Protein...
12. In a porcine model, reprogrammed PGCs were induced by the addition of follicular fluid, insulin transferrin selenium (ITS) and follicle-stimulating hormone (FSH)13,14. In humans, fetuin, ITS, EGF, activin A, and BMP4 were reported to successfully induce PGC formation...