Our second model provided a better overall fit of TM7 and part of the TM6-7 loop into the experimental density. In addition, the second model revealed two potential hydrogen bonds between the side chain carboxamide of TM7 residue N300 and the R-4 backbone amide and carbonyl of KZR-8445 ...
(Fig.2cand Supplementary Fig.2). Rad51 promotes replication restart at arrested forks and protects them from uncontrolled end-resection to facilitate merging with opposite forks. To distinguish between these two Rad51 functions, we analyzed therad51-II3Amutant that binds DNA to protect forks but...
developed an analytical model that captures the essential elements of LND translocation through pores (Supplementary Modelling Discussion). These calculations suggest that in many cases where the size of the disc is slightly larger than the size of the constriction (for example, between 10% and 20%...
In a simi- lar line of argument, a universal RNAPII CTD cycle along genes has been proposed, which is orchestrated by complex interplays between kinases, phosphatases and proline isomerases46. The determination of the minimal distances required between the two general phospho- rylation marks Ser5...
In this article, we discuss the remarkable connection between two very different fields, number theory and nuclear physics. We describe the essential aspects of these fields, the quantities studied, and how insights in one have been fruitfully applied in the other. The exciting branch of modern ...